2omm

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[[Image:2omm.png|left|200px]]
 
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==GNNQQNY peptide corresponding to residues 7-13 of yeast prion sup35==
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The line below this paragraph, containing "STRUCTURE_2omm", creates the "Structure Box" on the page.
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<StructureSection load='2omm' size='340' side='right'caption='[[2omm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2omm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OMM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2omm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2omm OCA], [https://pdbe.org/2omm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2omm RCSB], [https://www.ebi.ac.uk/pdbsum/2omm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2omm ProSAT]</span></td></tr>
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{{STRUCTURE_2omm| PDB=2omm | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERF3_YEAST ERF3_YEAST] Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides. Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs. Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.<ref>PMID:7556078</ref> <ref>PMID:12923185</ref> <ref>PMID:15337765</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNY of the yeast prion protein Sup35, was recently revealed by X-ray microcrystallography. It is a pair of beta-sheets, with the facing side chains of the two sheets interdigitated in a dry 'steric zipper'. Here we report some 30 other segments from fibril-forming proteins that form amyloid-like fibrils, microcrystals, or usually both. These include segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. Structures of 13 of these microcrystals all reveal steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains.
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===GNNQQNY peptide corresponding to residues 7-13 of yeast prion sup35===
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Atomic structures of amyloid cross-beta spines reveal varied steric zippers.,Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:17468747<ref>PMID:17468747</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2omm" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17468747}}, adds the Publication Abstract to the page
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*[[Prion 3D structures|Prion 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17468747 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17468747}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2omm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMM OCA].
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Eisenberg D]]
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==Reference==
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[[Category: Nelson R]]
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<ref group="xtra">PMID:17468747</ref><references group="xtra"/>
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[[Category: Sawaya MR]]
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[[Category: Eisenberg, D.]]
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[[Category: Nelson, R.]]
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[[Category: Sawaya, M R.]]
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Current revision

GNNQQNY peptide corresponding to residues 7-13 of yeast prion sup35

PDB ID 2omm

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