2awx

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[[Image:2awx.png|left|200px]]
 
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==Synapse associated protein 97 PDZ2 domain variant C378S==
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The line below this paragraph, containing "STRUCTURE_2awx", creates the "Structure Box" on the page.
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<StructureSection load='2awx' size='340' side='right'caption='[[2awx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2awx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AWX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>
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{{STRUCTURE_2awx| PDB=2awx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2awx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awx OCA], [https://pdbe.org/2awx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2awx RCSB], [https://www.ebi.ac.uk/pdbsum/2awx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2awx ProSAT]</span></td></tr>
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</table>
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===Synapse associated protein 97 PDZ2 domain variant C378S===
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== Function ==
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[https://www.uniprot.org/uniprot/DLG1_RAT DLG1_RAT] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.<ref>PMID:14960569</ref> <ref>PMID:15044483</ref> <ref>PMID:15504326</ref> <ref>PMID:19213956</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_17069616}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17069616 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aw/2awx_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17069616}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2awx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWX OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2awx ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:17069616</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Cai, C.]]
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[[Category: Cai C]]
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[[Category: Goldman, A.]]
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[[Category: Goldman A]]
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[[Category: Keinanen, K.]]
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[[Category: Keinanen K]]
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[[Category: Oksanen, E.]]
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[[Category: Oksanen E]]
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[[Category: Ossowski, I Von.]]
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[[Category: Sundberg M]]
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[[Category: Ossowski, L Von.]]
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[[Category: Von Ossowski I]]
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[[Category: Sundberg, M.]]
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[[Category: Von Ossowski L]]

Current revision

Synapse associated protein 97 PDZ2 domain variant C378S

PDB ID 2awx

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