2ecl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:49, 29 May 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ecl.jpg|left|200px]]<br /><applet load="2ecl" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2ecl" />
 
-
'''Solution Structure of the RING domain of the human RING-box protein 2'''<br />
 
-
==About this Structure==
+
==Solution Structure of the RING domain of the human RING-box protein 2==
-
2ECL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECL OCA].
+
<StructureSection load='2ecl' size='340' side='right'caption='[[2ecl]]' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2ecl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECL FirstGlance]. <br>
-
[[Category: Harada, T.]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
[[Category: Kigawa, T.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Koshiba, S.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecl OCA], [https://pdbe.org/2ecl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecl RCSB], [https://www.ebi.ac.uk/pdbsum/2ecl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecl ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecl TOPSAN]</span></td></tr>
-
[[Category: Miyamoto, K.]]
+
</table>
-
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+
== Function ==
-
[[Category: Tomizawa, T.]]
+
[https://www.uniprot.org/uniprot/RBX2_HUMAN RBX2_HUMAN] Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.<ref>PMID:10851089</ref>
-
[[Category: Watanabe, S.]]
+
== Evolutionary Conservation ==
-
[[Category: Yokoyama, S.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: ZN]]
+
Check<jmol>
-
[[Category: metal binding protein]]
+
<jmolCheckbox>
-
[[Category: national project on protein structural and functional analyses]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecl_consurf.spt"</scriptWhenChecked>
-
[[Category: nppsfa]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: riken structural genomics/proteomics initiative]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: ring domian]]
+
</jmolCheckbox>
-
[[Category: ring-box protein 2]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecl ConSurf].
-
[[Category: rnf7]]
+
<div style="clear:both"></div>
-
[[Category: rsgi]]
+
-
[[Category: structural genomics]]
+
-
[[Category: zinc-binding domain]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:10:17 2008''
+
==See Also==
 +
*[[Ring box protein 3D structures|Ring box protein 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Harada T]]
 +
[[Category: Kigawa T]]
 +
[[Category: Koshiba S]]
 +
[[Category: Miyamoto K]]
 +
[[Category: Tomizawa T]]
 +
[[Category: Watanabe S]]
 +
[[Category: Yokoyama S]]

Current revision

Solution Structure of the RING domain of the human RING-box protein 2

PDB ID 2ecl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ecl"
Personal tools