2yan

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'''Unreleased structure'''
 
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The entry 2yan is ON HOLD
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==Crystal structure of the second glutaredoxin domain of human TXNL2==
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<StructureSection load='2yan' size='340' side='right'caption='[[2yan]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Vollmar, M., Johansson, C., Cocking, R., Muniz, J.R.C., Krojer, T., Allerston, C., VonDelft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2yan]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YAN FirstGlance]. <br>
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Description: Crystal structure of the second glutaredoxin domain of human TXNL2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yan OCA], [https://pdbe.org/2yan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yan RCSB], [https://www.ebi.ac.uk/pdbsum/2yan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yan ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLRX3_HUMAN GLRX3_HUMAN] Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Allerston C]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Cocking R]]
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[[Category: Edwards A]]
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[[Category: Johansson C]]
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[[Category: Krojer T]]
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[[Category: Muniz JRC]]
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[[Category: Oppermann U]]
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[[Category: Vollmar M]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the second glutaredoxin domain of human TXNL2

PDB ID 2yan

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OCA

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