3qwm

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(New page: '''Unreleased structure''' The entry 3qwm is ON HOLD Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Feller, S., Janning, M., Sabe, H., Krojer, T., Chaikuad, A., Allerston, C., ...)
Current revision (08:35, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3qwm is ON HOLD
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==Crystal Structure of GEP100, the plextrin homology domain of IQ motif and SEC7 domain-containing protein 1 isoform a==
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<StructureSection load='3qwm' size='340' side='right'caption='[[3qwm]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Feller, S., Janning, M., Sabe, H., Krojer, T., Chaikuad, A., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qwm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWM FirstGlance]. <br>
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Description: Crystal Structure of GEP100, the plextrin homology domain of IQ motif and SEC7 domain-containing protein 1 isoform a
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwm OCA], [https://pdbe.org/3qwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwm RCSB], [https://www.ebi.ac.uk/pdbsum/3qwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IQEC1_HUMAN IQEC1_HUMAN] In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.<ref>PMID:11226253</ref> <ref>PMID:16461286</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Allerston C]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Chaikuad A]]
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[[Category: Edwards A]]
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[[Category: Feller S]]
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[[Category: Felletar I]]
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[[Category: Filippakopoulos P]]
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[[Category: Janning M]]
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[[Category: Knapp S]]
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[[Category: Krojer T]]
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[[Category: Picaud S]]
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[[Category: Sabe H]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal Structure of GEP100, the plextrin homology domain of IQ motif and SEC7 domain-containing protein 1 isoform a

PDB ID 3qwm

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