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2dvs

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[[Image:2dvs.jpg|left|200px]]<br /><applet load="2dvs" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dvs, resolution 2.04&Aring;" />
 
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'''Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide'''<br />
 
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==About this Structure==
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==Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide==
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2DVS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DVS OCA].
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<StructureSection load='2dvs' size='340' side='right'caption='[[2dvs]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2dvs]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DVS FirstGlance]. <br>
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[[Category: Nakamura, Y.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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[[Category: Padmanabhan, B.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dvs OCA], [https://pdbe.org/2dvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dvs RCSB], [https://www.ebi.ac.uk/pdbsum/2dvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dvs ProSAT], [https://www.topsan.org/Proteins/RSGI/2dvs TOPSAN]</span></td></tr>
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[[Category: Shirouzu, M.]]
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</table>
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[[Category: Umehara, T.]]
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== Function ==
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[[Category: Yokoyama, S.]]
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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[[Category: alpha-helical domain]]
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== Evolutionary Conservation ==
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[[Category: binds to acetylated histones]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: bromodomain]]
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Check<jmol>
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[[Category: national project on protein structural and functional analyses]]
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<jmolCheckbox>
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[[Category: nppsfa]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/2dvs_consurf.spt"</scriptWhenChecked>
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[[Category: riken structural genomics/proteomics initiative]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: rsgi]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: structural genomics]]
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</jmolCheckbox>
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[[Category: transcription]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dvs ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:15:05 2008''
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Nakamura Y]]
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[[Category: Padmanabhan B]]
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[[Category: Shirouzu M]]
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[[Category: Umehara T]]
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[[Category: Yokoyama S]]

Current revision

Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide

PDB ID 2dvs

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