1hku

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[[Image:1hku.png|left|200px]]
 
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==CtBP/BARS: a dual-function protein involved in transcription corepression and Golgi membrane fission==
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The line below this paragraph, containing "STRUCTURE_1hku", creates the "Structure Box" on the page.
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<StructureSection load='1hku' size='340' side='right'caption='[[1hku]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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{{STRUCTURE_1hku| PDB=1hku | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hku OCA], [https://pdbe.org/1hku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hku RCSB], [https://www.ebi.ac.uk/pdbsum/1hku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hku ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hku_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hku ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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C-terminal-binding protein/brefeldin A-ADP ribosylated substrate (CtBP/BARS) plays key roles in development and oncogenesis as a transcription co-repressor, and in intracellular traffic as a promoter of Golgi membrane fission. Co-repressor activity is regulated by NAD(H) binding to CtBP/BARS, while membrane fission is associated with its acyl-CoA-dependent acyltransferase activity. Here, we report the crystal structures of rat CtBP/BARS in a binary complex with NAD(H), and in a ternary complex with a PIDLSKK peptide mimicking the consensus motif (PXDLS) recognized in CtBP/BARS cellular partners. The structural data show CtBP/BARS in a NAD(H)-bound dimeric form; the peptide binding maps the recognition site for DNA-binding proteins and histone deacetylases to an N-terminal region of the protein. The crystal structure together with the site-directed mutagenesis data and binding experiments suggest a rationale for the molecular mechanisms underlying the two fundamental co-existing, but diverse, activities supported by CtBP/BARS in the nucleus and in Golgi membranes.
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===CTBP/BARS: A DUAL-FUNCTION PROTEIN INVOLVED IN TRANSCRIPTION COREPRESSION AND GOLGI MEMBRANE FISSION===
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CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission.,Nardini M, Spano S, Cericola C, Pesce A, Massaro A, Millo E, Luini A, Corda D, Bolognesi M EMBO J. 2003 Jun 16;22(12):3122-30. PMID:12805226<ref>PMID:12805226</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12805226}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1hku" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12805226 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12805226}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1hku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKU OCA].
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==Reference==
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<ref group="xtra">PMID:12805226</ref><ref group="xtra">PMID:12037320</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Cericola, C.]]
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[[Category: Cericola C]]
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[[Category: Corda, D.]]
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[[Category: Corda D]]
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[[Category: Luini, A.]]
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[[Category: Luini A]]
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[[Category: Massaro, A.]]
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[[Category: Massaro A]]
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[[Category: Millo, E.]]
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[[Category: Millo E]]
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[[Category: Nardini, M.]]
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[[Category: Nardini M]]
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[[Category: Pesce, A.]]
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[[Category: Pesce A]]
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[[Category: Spano , S.]]
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[[Category: Spano S]]
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[[Category: Acyl-coa]]
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[[Category: Acyltransferase]]
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[[Category: Brefeldin some]]
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[[Category: Golgi membrane]]
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[[Category: Nad]]
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[[Category: Transcription co-repression]]
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[[Category: Transcription co-repressor]]
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Current revision

CtBP/BARS: a dual-function protein involved in transcription corepression and Golgi membrane fission

PDB ID 1hku

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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