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1hku

From Proteopedia

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[[Image:1hku.png|left|200px]]
 
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==CtBP/BARS: a dual-function protein involved in transcription corepression and Golgi membrane fission==
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The line below this paragraph, containing "STRUCTURE_1hku", creates the "Structure Box" on the page.
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<StructureSection load='1hku' size='340' side='right'caption='[[1hku]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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{{STRUCTURE_1hku| PDB=1hku | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hku OCA], [https://pdbe.org/1hku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hku RCSB], [https://www.ebi.ac.uk/pdbsum/1hku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hku ProSAT]</span></td></tr>
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</table>
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===CTBP/BARS: A DUAL-FUNCTION PROTEIN INVOLVED IN TRANSCRIPTION COREPRESSION AND GOLGI MEMBRANE FISSION===
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== Function ==
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[https://www.uniprot.org/uniprot/CTBP1_RAT CTBP1_RAT] Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Functions in brown adipose tissue (BAT) differentiation.<ref>PMID:10364211</ref> <ref>PMID:7624370</ref> <ref>PMID:12805226</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12805226}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12805226 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hku_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12805226}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1hku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKU OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hku ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:12805226</ref><ref group="xtra">PMID:12037320</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Cericola, C.]]
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[[Category: Cericola C]]
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[[Category: Corda, D.]]
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[[Category: Corda D]]
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[[Category: Luini, A.]]
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[[Category: Luini A]]
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[[Category: Massaro, A.]]
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[[Category: Massaro A]]
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[[Category: Millo, E.]]
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[[Category: Millo E]]
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[[Category: Nardini, M.]]
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[[Category: Nardini M]]
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[[Category: Pesce, A.]]
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[[Category: Pesce A]]
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[[Category: Spano , S.]]
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[[Category: Spano S]]
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[[Category: Acyl-coa]]
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[[Category: Acyltransferase]]
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[[Category: Brefeldin some]]
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[[Category: Golgi membrane]]
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[[Category: Nad]]
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[[Category: Transcription co-repression]]
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[[Category: Transcription co-repressor]]
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Current revision

CtBP/BARS: a dual-function protein involved in transcription corepression and Golgi membrane fission

PDB ID 1hku

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OCA

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