3fe3

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[[Image:3fe3.png|left|200px]]
 
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==Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant==
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The line below this paragraph, containing "STRUCTURE_3fe3", creates the "Structure Box" on the page.
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<StructureSection load='3fe3' size='340' side='right'caption='[[3fe3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fe3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FE3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe3 OCA], [https://pdbe.org/3fe3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fe3 RCSB], [https://www.ebi.ac.uk/pdbsum/3fe3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe3 ProSAT]</span></td></tr>
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{{STRUCTURE_3fe3| PDB=3fe3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MARK3_HUMAN MARK3_HUMAN] Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.<ref>PMID:16980613</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Ser/Thr kinase MARK2 phosphorylates tau protein at sites that cause detachment from microtubules in Alzheimer neurofibrillary degeneration. Homologs of MARK2 include Par-1 in C. elegans and Drosophila, which generates embryonic polarity. We report the X-ray structure of the catalytic and ubiquitin-associated domains (UBA) of human MARK2. The activity was altered by mutations in the ATP binding site and/or activation loop. The catalytic domain shows the small and large lobes typical of kinases. The substrate cleft is in an inactive, open conformation in the inactivated and the wild-type structure. The UBA domain is attached via a taut linker to the large lobe of the kinase domain and leans against a hydrophobic patch on the small lobe. The UBA structure is unusual because the orientation of its third helix is inverted, relative to previous structures. Possible implications of the structure for the regulation of kinase activity are discussed.
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===Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant===
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Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.,Panneerselvam S, Marx A, Mandelkow EM, Mandelkow E Structure. 2006 Feb;14(2):173-83. PMID:016472737<ref>PMID:016472737</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3fe3" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16472737}}, adds the Publication Abstract to the page
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16472737 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16472737}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3fe3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE3 OCA].
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==Reference==
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<ref group="xtra">PMID:16472737</ref><ref group="xtra">PMID:16803889</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Mandelkow, E.]]
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[[Category: Mandelkow E]]
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[[Category: Mandelkow, E M.]]
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[[Category: Mandelkow E-M]]
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[[Category: Marx, A.]]
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[[Category: Marx A]]
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[[Category: Nugoor, C.]]
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[[Category: Nugoor C]]
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[[Category: Panneerselvam, S.]]
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[[Category: Panneerselvam S]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: C-tak1]]
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[[Category: Kin1]]
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[[Category: Kinase]]
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[[Category: Mark]]
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[[Category: Mark3]]
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[[Category: Nucleotide-binding]]
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[[Category: P78]]
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[[Category: Par-1]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Serine/threonine protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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[[Category: Uba domain]]
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Current revision

Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant

PDB ID 3fe3

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