2dcv

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[[Image:2dcv.png|left|200px]]
 
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==The solution structure of horseshoe crab antimicrobial peptide tachystatin b with the inhibitory cystine-knot motif==
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The line below this paragraph, containing "STRUCTURE_2dcv", creates the "Structure Box" on the page.
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<StructureSection load='2dcv' size='340' side='right'caption='[[2dcv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dcv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DCV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dcv OCA], [https://pdbe.org/2dcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dcv RCSB], [https://www.ebi.ac.uk/pdbsum/2dcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dcv ProSAT]</span></td></tr>
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{{STRUCTURE_2dcv| PDB=2dcv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TACB1_TACTR TACB1_TACTR] Exhibits stronger antimicrobial activity against the Gram-positive bacteria (S.aureus (IC(50) is 7.4 ug/ml)) and fungi (C.albicans (IC(50) is 3.0 ug/ml) and P.pastoris (IC(50) is 0.1 ug/ml)) than Gram-negative bacteria (E.coli no inhibition at 100 ug/ml). Binds to chitin (4.3 uM are required to obtain 50% of binding). Does not cause hemolysis on sheep erythrocytes. Has no blocking activity on the P-type calcium channel.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tachystatin B is an antimicrobial and a chitin-binding peptide isolated from the Japanese horseshoe crab (Tachypleus tridentatus) consisting of two isopeptides called tachystatin B1 and B2. We have determined their solution structures using NMR experiments and distance geometry calculations. The 20 best converged structures of tachystatin B1 and B2 exhibited root mean square deviations of 0.46 and 0.49 A, respectively, for the backbone atoms in Cys(4)-Arg(40). Both structures have identical conformations, and they contain a short antiparallel beta-sheet with an inhibitory cystine-knot (ICK) motif that is distributed widely in the antagonists for voltage-gated ion channels, although tachystatin B does not have neurotoxic activity. The structural homology search provided several peptides with structures similar to that of tachystatin B. However, most of them have the advanced functions such as insecticidal activity, suggesting that tachystatin B may be a kind of ancestor of antimicrobial peptide in the molecular evolutionary history. Tachystatin B also displays a significant structural similarity to tachystatin A, which is member of the tachystatin family. The structural comparison of both tachystatins indicated that Tyr(14) and Arg(17) in the long loop between the first and second strands might be the essential residues for binding to chitin.
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===The solution structure of horseshoe crab antimicrobial peptide tachystatin b with the inhibitory cystine-knot motif===
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The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif.,Fujitani N, Kouno T, Nakahara T, Takaya K, Osaki T, Kawabata S, Mizuguchi M, Aizawa T, Demura M, Nishimura S, Kawano K J Pept Sci. 2007 Apr;13(4):269-79. PMID:17394123<ref>PMID:17394123</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17394123}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2dcv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17394123 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17394123}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2dcv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DCV OCA].
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==Reference==
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<ref group="xtra">PMID:17394123</ref><ref group="xtra">PMID:10473569</ref><references group="xtra"/>
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[[Category: Tachypleus tridentatus]]
[[Category: Tachypleus tridentatus]]
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[[Category: Fujitani, N.]]
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[[Category: Fujitani N]]
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[[Category: Kohno, T.]]
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[[Category: Kohno T]]
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[[Category: Antimicrobial]]
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[[Category: Antimicrobial protein]]
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[[Category: Cystine-knot]]
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Current revision

The solution structure of horseshoe crab antimicrobial peptide tachystatin b with the inhibitory cystine-knot motif

PDB ID 2dcv

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