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1dxj

From Proteopedia

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[[Image:1dxj.png|left|200px]]
 
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==Structure of the chitinase from jack bean==
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The line below this paragraph, containing "STRUCTURE_1dxj", creates the "Structure Box" on the page.
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<StructureSection load='1dxj' size='340' side='right'caption='[[1dxj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dxj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DXJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1dxj| PDB=1dxj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxj OCA], [https://pdbe.org/1dxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dxj RCSB], [https://www.ebi.ac.uk/pdbsum/1dxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O81934_CANEN O81934_CANEN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/1dxj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dxj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of jack bean chitinase was solved at 1.8 A resolution by molecular replacement. It is an alpha-helical protein with three disulfide bridges. The active site is related in structure to animal and viral lysozymes. However, unlike in lysozyme, the architecture of the active site suggests a single-step cleavage. According to this mechanism, Glu68 is the proton donor and Glu90 assists in the reaction by moving towards the substrate and recruiting a water molecule that acts as the nucleophile. In this model, a water molecule was found in contact with Glu90 O(epsilon1) and Thr119 O(gamma) at a distance of 3.0 and 2.8 A, respectively. The model is in accordance with the observed inversion mechanism.
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===STRUCTURE OF THE CHITINASE FROM JACK BEAN===
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Structure of jack bean chitinase.,Hahn M, Hennig M, Schlesier B, Hohne W Acta Crystallogr D Biol Crystallogr. 2000 Sep;56(Pt 9):1096-9. PMID:10957628<ref>PMID:10957628</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1dxj" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10957628}}, adds the Publication Abstract to the page
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*[[Chitinase 3D structures|Chitinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10957628 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10957628}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1dxj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXJ OCA].
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==Reference==
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<ref group="xtra">PMID:10957628</ref><ref group="xtra">PMID:15299702</ref><ref group="xtra">PMID:8421299</ref><references group="xtra"/>
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[[Category: Canavalia ensiformis]]
[[Category: Canavalia ensiformis]]
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[[Category: Chitinase]]
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[[Category: Large Structures]]
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[[Category: Hahn, M.]]
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[[Category: Hahn M]]
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[[Category: Hennig, M.]]
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[[Category: Hennig M]]
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[[Category: Hohne, W.]]
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[[Category: Hohne W]]
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[[Category: Schlesier, B.]]
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[[Category: Schlesier B]]
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[[Category: Alpha helical protein]]
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[[Category: Family 19 glycosidase]]
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[[Category: Hydrolase]]
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Current revision

Structure of the chitinase from jack bean

PDB ID 1dxj

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