1h5c

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[[Image:1h5c.png|left|200px]]
 
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==X-ray induced reduction of horseradish peroxidase C1A Compound III (100-200% dose)==
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The line below this paragraph, containing "STRUCTURE_1h5c", creates the "Structure Box" on the page.
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<StructureSection load='1h5c' size='340' side='right'caption='[[1h5c]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H5C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_1h5c| PDB=1h5c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h5c OCA], [https://pdbe.org/1h5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h5c RCSB], [https://www.ebi.ac.uk/pdbsum/1h5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h5c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PER1A_ARMRU PER1A_ARMRU] Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/1h5c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h5c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A molecular description of oxygen and peroxide activation in biological systems is difficult, because electrons liberated during X-ray data collection reduce the active centres of redox enzymes catalysing these reactions. Here we describe an effective strategy to obtain crystal structures for high-valency redox intermediates and present a three-dimensional movie of the X-ray-driven catalytic reduction of a bound dioxygen species in horseradish peroxidase (HRP). We also describe separate experiments in which high-resolution structures could be obtained for all five oxidation states of HRP, showing such structures with preserved redox states for the first time.
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===X-RAY INDUCED REDUCTION OF HORSERADISH PEROXIDASE C1A COMPOUND III (100-200% DOSE)===
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The catalytic pathway of horseradish peroxidase at high resolution.,Berglund GI, Carlsson GH, Smith AT, Szoke H, Henriksen A, Hajdu J Nature. 2002 May 23;417(6887):463-8. PMID:12024218<ref>PMID:12024218</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1h5c" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12024218}}, adds the Publication Abstract to the page
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*[[Horseradish peroxidase|Horseradish peroxidase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12024218 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12024218}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1h5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5C OCA].
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==Reference==
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<ref group="xtra">PMID:12024218</ref><ref group="xtra">PMID:10574977</ref><ref group="xtra">PMID:9406554</ref><ref group="xtra">PMID:2198290</ref><references group="xtra"/>
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[[Category: Armoracia rusticana]]
[[Category: Armoracia rusticana]]
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[[Category: Peroxidase]]
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[[Category: Large Structures]]
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[[Category: Berglund, G I.]]
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[[Category: Berglund GI]]
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[[Category: Carlsson, G H.]]
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[[Category: Carlsson GH]]
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[[Category: Hajdu, J.]]
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[[Category: Hajdu J]]
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[[Category: Henriksen, A.]]
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[[Category: Henriksen A]]
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[[Category: Smith, A T.]]
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[[Category: Smith AT]]
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[[Category: Szoke, H.]]
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[[Category: Szoke H]]
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[[Category: Compound iii]]
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[[Category: Horseradish]]
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[[Category: Oxidoreductase]]
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[[Category: Oxyperoxidase]]
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[[Category: Peroxidase]]
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[[Category: X-ray induced reduction]]
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Current revision

X-ray induced reduction of horseradish peroxidase C1A Compound III (100-200% dose)

PDB ID 1h5c

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