1x8i

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[[Image:1x8i.png|left|200px]]
 
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==Crystal Structure of the Zinc Carbapenemase CphA in Complex with the Antibiotic Biapenem==
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The line below this paragraph, containing "STRUCTURE_1x8i", creates the "Structure Box" on the page.
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<StructureSection load='1x8i' size='340' side='right'caption='[[1x8i]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x8i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X8I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMH:5H-PYRAZOLO(1,2-A)(1,2,4)TRIAZOL-4-IUM,+6-((2-CARBOXY-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO(3.2.0)HEPT-2-EN-3-YL)THIO)-6,7-DIHYDRO-,+HYDROXIDE,+INNER+SALT,+(4R-(4ALPHA,5BETA,6BETA(R*)))-'>BMH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1x8i| PDB=1x8i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x8i OCA], [https://pdbe.org/1x8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x8i RCSB], [https://www.ebi.ac.uk/pdbsum/1x8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x8i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAB_AERHY BLAB_AERHY] Can hydrolyze carbapenem compounds.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/1x8i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x8i ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Zinc Carbapenemase CphA in Complex with the Antibiotic Biapenem===
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15588826}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15588826 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15588826}}
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==About this Structure==
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[[1x8i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X8I OCA].
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==Reference==
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<ref group="xtra">PMID:15588826</ref><ref group="xtra">PMID:15215079</ref><ref group="xtra">PMID:7588620</ref><ref group="xtra">PMID:12507470</ref><references group="xtra"/>
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[[Category: Aeromonas hydrophila]]
[[Category: Aeromonas hydrophila]]
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Dideberg, O.]]
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[[Category: Dideberg O]]
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[[Category: Garau, G.]]
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[[Category: Garau G]]
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[[Category: Hydrolase]]
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Current revision

Crystal Structure of the Zinc Carbapenemase CphA in Complex with the Antibiotic Biapenem

PDB ID 1x8i

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