2obe

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[[Image:2obe.png|left|200px]]
 
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==Crystal Structure of Chimpanzee Adenovirus (Type 68/Simian 25) Major Coat Protein Hexon==
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The line below this paragraph, containing "STRUCTURE_2obe", creates the "Structure Box" on the page.
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<StructureSection load='2obe' size='340' side='right'caption='[[2obe]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2obe]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_adenovirus_25 Simian adenovirus 25]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OBE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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{{STRUCTURE_2obe| PDB=2obe | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2obe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2obe OCA], [https://pdbe.org/2obe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2obe RCSB], [https://www.ebi.ac.uk/pdbsum/2obe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2obe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8UY79_9ADEN Q8UY79_9ADEN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/2obe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2obe ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Virus-specific neutralizing antibodies present an obstacle to the effective use of adenovirus vectors for gene therapy and vaccination. The specific sites recognized by neutralizing antibodies have not been identified for any adenovirus, but they have been proposed to reside within the hexon, in small regions of the molecule that are exposed on the capsid surface and possess sequences that vary among serotypes. We have mapped the epitopes recognized by a panel of seven hexon-specific monoclonal antibodies that neutralize the chimpanzee adenovirus 68 (AdC68). Surface plasmon resonance experiments revealed that the antibodies compete for a single hexon binding site, and experiments with synthetic peptides indicated that this site resides within just one small surface loop. Mutations within this loop (but not in other surface loops) permitted virus to escape neutralization by all seven monoclonal antibodies and to resist neutralization by polyclonal antisera obtained from animals immunized against AdC68. These results indicate that a single small surface loop defines a major neutralization site for AdC68 hexon.
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===Crystal Structure of Chimpanzee Adenovirus (Type 68/Simian 25) Major Coat Protein Hexon===
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Structure-based identification of a major neutralizing site in an adenovirus hexon.,Pichla-Gollon SL, Drinker M, Zhou X, Xue F, Rux JJ, Gao GP, Wilson JM, Ertl HC, Burnett RM, Bergelson JM J Virol. 2007 Feb;81(4):1680-9. Epub 2006 Nov 15. PMID:17108028<ref>PMID:17108028</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2obe" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17108028}}, adds the Publication Abstract to the page
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17108028 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17108028}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2obe]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_adenovirus_25 Simian adenovirus 25]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBE OCA].
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==Reference==
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<ref group="xtra">PMID:17108028</ref><ref group="xtra">PMID:16458021</ref><references group="xtra"/>
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[[Category: Simian adenovirus 25]]
[[Category: Simian adenovirus 25]]
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[[Category: Burnett, R M.]]
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[[Category: Burnett RM]]
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[[Category: Rux, J J.]]
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[[Category: Rux JJ]]
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[[Category: Xue, F.]]
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[[Category: Xue F]]
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[[Category: Base]]
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[[Category: Double-barrel subunit]]
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[[Category: Hypervariable tower]]
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[[Category: Trimer]]
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[[Category: Viral jellyroll]]
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[[Category: Viral protein]]
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Current revision

Crystal Structure of Chimpanzee Adenovirus (Type 68/Simian 25) Major Coat Protein Hexon

PDB ID 2obe

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