1dxs

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[[Image:1dxs.png|left|200px]]
 
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==Crystal structure of the C-terminal sterile alpha motif (SAM) domain of human p73 alpha splice variant==
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The line below this paragraph, containing "STRUCTURE_1dxs", creates the "Structure Box" on the page.
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<StructureSection load='1dxs' size='340' side='right'caption='[[1dxs]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DXS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxs OCA], [https://pdbe.org/1dxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dxs RCSB], [https://www.ebi.ac.uk/pdbsum/1dxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxs ProSAT]</span></td></tr>
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{{STRUCTURE_1dxs| PDB=1dxs | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/1dxs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dxs ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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p73 is a homologue of the tumour suppressor p53 and contains all three functional domains of p53. The alpha-splice variant of p73 (p73 alpha) contains near its C-terminus an additional structural domain known as the sterile alpha-motif (SAM) that is probably responsible for regulating p53-like functions of p73. Here, the 2.54 A resolution crystal structure of this protein domain is reported. The crystal structure and the published solution structure have the same five-helix bundle fold that is characteristic of all SAM-domain structures, with an overall r.m.s.d. of 1.5 A for main-chain atoms. The hydrophobic core residues are well conserved, yet some large local differences are observed. The crystal structure reveals a dimeric organization, with the interface residues forming a mini four-helix bundle. However, analysis of solvation free energies and the surface area buried upon dimer formation indicated that this arrangement is more likely to be an effect of crystal packing rather than reflecting a physiological state. This is consistent with the solution structure being a monomer. The p73 alpha SAM domain also contains several interesting structural features: a Cys-X-X-Cys motif, a 3(10)-helix and a loop that have elevated B factors, and short tight inter-helical loops including two beta-turns; these elements are probably important in the normal function of this domain.
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===CRYSTAL STRUCTURE OF THE C-TERMINAL STERILE ALPHA MOTIF (SAM) DOMAIN OF HUMAN P73 ALPHA SPLICE VARIANT===
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Structure of the C-terminal sterile alpha-motif (SAM) domain of human p73 alpha.,Wang WK, Bycroft M, Foster NW, Buckle AM, Fersht AR, Chen YW Acta Crystallogr D Biol Crystallogr. 2001 Apr;57(Pt 4):545-51. PMID:11264583<ref>PMID:11264583</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11264583}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1dxs" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11264583 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11264583}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1dxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXS OCA].
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==Reference==
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<ref group="xtra">PMID:11264583</ref><ref group="xtra">PMID:10818360</ref><ref group="xtra">PMID:10449409</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, Y W.]]
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[[Category: Large Structures]]
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[[Category: Wang, W K.]]
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[[Category: Chen YW]]
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[[Category: Gene regulation]]
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[[Category: Wang WK]]
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[[Category: P53 p63 homologue]]
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[[Category: P73 sam-like domain]]
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[[Category: Sterile alpha motif]]
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[[Category: Tumour supressor]]
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Current revision

Crystal structure of the C-terminal sterile alpha motif (SAM) domain of human p73 alpha splice variant

PDB ID 1dxs

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