1pk0

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[[Image:1pk0.png|left|200px]]
 
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==Crystal Structure of the EF3-CaM complexed with PMEApp==
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The line below this paragraph, containing "STRUCTURE_1pk0", creates the "Structure Box" on the page.
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<StructureSection load='1pk0' size='340' side='right'caption='[[1pk0]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pk0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PK0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EMA:(ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE'>EMA</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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{{STRUCTURE_1pk0| PDB=1pk0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pk0 OCA], [https://pdbe.org/1pk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pk0 RCSB], [https://www.ebi.ac.uk/pdbsum/1pk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pk0 ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of the EF3-CaM complexed with PMEApp===
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== Function ==
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[https://www.uniprot.org/uniprot/CYAA_BACAN CYAA_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 14978283 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pk0_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_14978283}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1pk0]] is a 6 chain structure of [[Adenylyl cyclase]] and [[Calmodulin]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PK0 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pk0 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Adenylyl cyclase]]
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*[[Anthrax edema factor|Anthrax edema factor]]
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*[[Calmodulin]]
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*[[Anthrax edema factor 3D structures|Anthrax edema factor 3D structures]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:14978283</ref><ref group="xtra">PMID:12485993</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Adenylate cyclase]]
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[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Shen, Y.]]
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[[Category: Large Structures]]
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[[Category: Tang, W J.]]
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[[Category: Shen Y]]
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[[Category: Cam]]
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[[Category: Tang WJ]]
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[[Category: Edema factor]]
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[[Category: Lyase/metal binding protein complex]]
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[[Category: Prodrug complex]]
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Current revision

Crystal Structure of the EF3-CaM complexed with PMEApp

PDB ID 1pk0

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