1h05

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[[Image:1h05.png|left|200px]]
 
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==3-DEHYDROQUINATE DEHYDRATASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH SULPHATE==
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The line below this paragraph, containing "STRUCTURE_1h05", creates the "Structure Box" on the page.
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<StructureSection load='1h05' size='340' side='right'caption='[[1h05]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H05 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1h05| PDB=1h05 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h05 OCA], [https://pdbe.org/1h05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h05 RCSB], [https://www.ebi.ac.uk/pdbsum/1h05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h05 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h05_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h05 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The interactions between the polyanionic ligands phosphate and sulphate and the type II dehydroquinases from Streptomyces coelicolor and Mycobacterium tuberculosis have been characterised using a combination of structural and kinetic methods. From both approaches, it is clear that interactions are more complex in the case of the latter enzyme. The data provide new insights into the differences between the two enzymes in terms of substrate recognition and catalytic efficiency and may also explain the relative potencies of rationally designed inhibitors. An improved route to the synthesis of the substrate 3-dehydroquinic acid (dehydroquinate) is described.
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===3-DEHYDROQUINATE DEHYDRATASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH SULPHATE===
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Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions.,Evans LD, Roszak AW, Noble LJ, Robinson DA, Chalk PA, Matthews JL, Coggins JR, Price NC, Lapthorn AJ FEBS Lett. 2002 Oct 23;530(1-3):24-30. PMID:12387860<ref>PMID:12387860</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1h05" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12387860}}, adds the Publication Abstract to the page
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*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12387860 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12387860}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1h05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H05 OCA].
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Coggins JR]]
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==Reference==
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[[Category: Lapthorn AJ]]
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<ref group="xtra">PMID:12387860</ref><ref group="xtra">PMID:10360352</ref><references group="xtra"/>
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[[Category: Roszak AW]]
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[[Category: 3-dehydroquinate dehydratase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Coggins, J R.]]
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[[Category: Lapthorn, A J.]]
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[[Category: Roszak, A W.]]
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[[Category: Alpha/beta protein]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Dehydratase]]
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[[Category: Lyase]]
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[[Category: Shikimate pathway]]
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Current revision

3-DEHYDROQUINATE DEHYDRATASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH SULPHATE

PDB ID 1h05

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