1wvf

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[[Image:1wvf.png|left|200px]]
 
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==p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon its Binding to the Cytochrome Subunit==
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The line below this paragraph, containing "STRUCTURE_1wvf", creates the "Structure Box" on the page.
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<StructureSection load='1wvf' size='340' side='right'caption='[[1wvf]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wvf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WVF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_1wvf| PDB=1wvf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wvf OCA], [https://pdbe.org/1wvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wvf RCSB], [https://www.ebi.ac.uk/pdbsum/1wvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wvf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DH4C_PSEPU DH4C_PSEPU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structures of two forms of a recombinant flavoprotein have been determined at high resolution and compared. These proteins are (1) the flavocytochrome c p-cresol methylhydroxylase (rPCMH, 1.85 A resolution) and (2) the cytochrome-free flavoprotein subunit of rPCMH (PchF, 1.30 A resolution). A significant conformational difference is observed in a protein segment that is in contact with the re face of the isoalloxazine ring of FAD when the structure of PchF is compared to the subunit in the intact flavocytochrome. This structural change is important for optimum catalytic function of the flavoprotein, which has been shown to be dependent on the presence of the cytochrome subunit. This change results in different protein-flavin and apparently different protein-substrate interactions that have a "tuning effect" on the electronic and redox properties of bound p-cresol and the covalently bound FAD. The conformational change in the segment in the cofactor-binding site is induced by a small rearrangement in the flavoprotein-cytochrome interface region of the flavoprotein.
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===p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon its Binding to the Cytochrome Subunit===
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p-Cresol methylhydroxylase: alteration of the structure of the flavoprotein subunit upon its binding to the cytochrome subunit.,Cunane LM, Chen ZW, McIntire WS, Mathews FS Biochemistry. 2005 Mar 1;44(8):2963-73. PMID:15723539<ref>PMID:15723539</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1wvf" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15723539 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15723539}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1wvf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WVF OCA].
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==Reference==
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<ref group="xtra">PMID:15723539</ref><ref group="xtra">PMID:10623531</ref><references group="xtra"/>
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[[Category: Pseudomonas putida]]
[[Category: Pseudomonas putida]]
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[[Category: Chen, Z W.]]
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[[Category: Chen Z-W]]
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[[Category: Cunane, L M.]]
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[[Category: Cunane LM]]
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[[Category: Mathews, F S.]]
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[[Category: Mathews FS]]
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[[Category: McIntire, W S.]]
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[[Category: McIntire WS]]
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[[Category: Electron-transfer]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Oxidoreductase]]
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Current revision

p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon its Binding to the Cytochrome Subunit

PDB ID 1wvf

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