2dwr

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[[Image:2dwr.png|left|200px]]
 
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==Crystal structure of the human Wa rotavirus VP8* carbohydrate-recognising domain==
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The line below this paragraph, containing "STRUCTURE_2dwr", creates the "Structure Box" on the page.
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<StructureSection load='2dwr' size='340' side='right'caption='[[2dwr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_rotavirus_A Human rotavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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{{STRUCTURE_2dwr| PDB=2dwr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwr OCA], [https://pdbe.org/2dwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwr RCSB], [https://www.ebi.ac.uk/pdbsum/2dwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VP4_ROTHW VP4_ROTHW] Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to the considered strain, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1. Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment. VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/2dwr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dwr ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the human Wa rotavirus VP8* carbohydrate-recognising domain===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_17306299}}, adds the Publication Abstract to the page
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[[Category: Human rotavirus A]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17306299 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Blanchard H]]
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{{ABSTRACT_PUBMED_17306299}}
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==About this Structure==
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[[2dwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_rotavirus_a Human rotavirus a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWR OCA].
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==Reference==
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<ref group="xtra">PMID:17306299</ref><ref group="xtra">PMID:16511215</ref><references group="xtra"/>
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[[Category: Human rotavirus a]]
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[[Category: Blanchard, H.]]
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[[Category: Beta-sandwich]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of the human Wa rotavirus VP8* carbohydrate-recognising domain

PDB ID 2dwr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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