1wza

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[[Image:1wza.png|left|200px]]
 
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==Crystal structure of alpha-amylase from H.orenii==
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The line below this paragraph, containing "STRUCTURE_1wza", creates the "Structure Box" on the page.
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<StructureSection load='1wza' size='340' side='right'caption='[[1wza]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wza]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halothermothrix_orenii Halothermothrix orenii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1wza| PDB=1wza | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wza OCA], [https://pdbe.org/1wza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wza RCSB], [https://www.ebi.ac.uk/pdbsum/1wza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wza ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8GPL8_9FIRM Q8GPL8_9FIRM]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wza_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wza ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here we report the first crystal structure of a protein, AmyA, a secretory alpha-amylase isolated from Halothermothrix orenii, which is both halophilic and thermophilic. The crystal structure was determined at 1.6 A resolution. AmyA lacks the conserved acidic surface, which is considered essential for protein stability at high salinity. Sedimentation velocity and CD experiments on AmyA reveal the formation of unique reversible poly-dispersed oligomers that show unusually high thermal stability. These studies provide valuable insight into the structural elements that contribute to the stability of AmyA at both physical and chemical extremes and their functional implications.
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===Crystal structure of alpha-amylase from H.orenii===
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Crystal structure of AmyA lacks acidic surface and provide insights into protein stability at poly-extreme condition.,Sivakumar N, Li N, Tang JW, Patel BK, Swaminathan K FEBS Lett. 2006 May 15;580(11):2646-52. Epub 2006 Apr 19. PMID:16647060<ref>PMID:16647060</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1wza" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16647060}}, adds the Publication Abstract to the page
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*[[Amylase 3D structures|Amylase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16647060 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16647060}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1wza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halothermothrix_orenii Halothermothrix orenii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZA OCA].
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==Reference==
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<ref group="xtra">PMID:16647060</ref><ref group="xtra">PMID:12177328</ref><references group="xtra"/>
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[[Category: Alpha-amylase]]
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[[Category: Halothermothrix orenii]]
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[[Category: Li, N.]]
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[[Category: Sivakumar, N.]]
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[[Category: Swaminathan, K.]]
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[[Category: Alpha amylase]]
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[[Category: Halophilic]]
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[[Category: Halothermothrix orenii]]
[[Category: Halothermothrix orenii]]
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[[Category: Hydrolase]]
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[[Category: Large Structures]]
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[[Category: Thermophilic]]
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[[Category: Li N]]
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[[Category: Sivakumar N]]
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[[Category: Swaminathan K]]

Current revision

Crystal structure of alpha-amylase from H.orenii

PDB ID 1wza

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