2i0i

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[[Image:2i0i.png|left|200px]]
 
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==X-ray crystal structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6==
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The line below this paragraph, containing "STRUCTURE_2i0i", creates the "Structure Box" on the page.
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<StructureSection load='2i0i' size='340' side='right'caption='[[2i0i]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2i0i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I0I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i0i OCA], [https://pdbe.org/2i0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i0i RCSB], [https://www.ebi.ac.uk/pdbsum/2i0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i0i ProSAT]</span></td></tr>
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{{STRUCTURE_2i0i| PDB=2i0i | SCENE= }}
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</table>
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== Function ==
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===X-ray crystal structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6===
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[https://www.uniprot.org/uniprot/DLG1_RAT DLG1_RAT] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.<ref>PMID:14960569</ref> <ref>PMID:15044483</ref> <ref>PMID:15504326</ref> <ref>PMID:19213956</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_17267502}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17267502 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/2i0i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17267502}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i0i ConSurf].
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[[2i0i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0I OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:17267502</ref><ref group="xtra">PMID:11571640</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Human papillomavirus type 18]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Banks, L.]]
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[[Category: Banks L]]
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[[Category: Chen, X S.]]
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[[Category: Chen XS]]
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[[Category: Dasgupta, J.]]
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[[Category: Dasgupta J]]
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[[Category: Thomas, M.]]
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[[Category: Thomas M]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: Cervical carcinoma]]
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[[Category: Hpv18 e6]]
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[[Category: Peptide binding protein]]
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[[Category: Sap97 pdz3]]
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[[Category: Tumor suppressor]]
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Current revision

X-ray crystal structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6

PDB ID 2i0i

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