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3nad

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[[Image:3nad.png|left|200px]]
 
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==Crystal Structure of Phenolic Acid Decarboxylase from Bacillus pumilus UI-670==
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The line below this paragraph, containing "STRUCTURE_3nad", creates the "Structure Box" on the page.
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<StructureSection load='3nad' size='340' side='right'caption='[[3nad]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3nad]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_pumilus Bacillus pumilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NAD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3nad| PDB=3nad | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nad OCA], [https://pdbe.org/3nad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nad RCSB], [https://www.ebi.ac.uk/pdbsum/3nad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nad ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q45361_BACPU Q45361_BACPU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The decarboxylation of phenolic acids, including ferulic and p-coumaric acids, to their corresponding vinyl derivatives is of importance in the flavouring and polymer industries. Here, the crystal structure of phenolic acid decarboxylase (PAD) from Bacillus pumilus strain UI-670 is reported. The enzyme is a 161-residue polypeptide that forms dimers both in the crystal and in solution. The structure of PAD as determined by X-ray crystallography revealed a beta-barrel structure and two alpha-helices, with a cleft formed at one edge of the barrel. The PAD structure resembles those of the lipocalin-fold proteins, which often bind hydrophobic ligands. Superposition of structurally related proteins bound to their cognate ligands shows that they and PAD bind their ligands in a conserved location within the beta-barrel. Analysis of the residue-conservation pattern for PAD-related sequences mapped onto the PAD structure reveals that the conservation mainly includes residues found within the hydrophobic core of the protein, defining a common lipocalin-like fold for this enzyme family. A narrow cleft containing several conserved amino acids was observed as a structural feature and a potential ligand-binding site.
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===Crystal Structure of Phenolic Acid Decarboxylase from Bacillus pumilus UI-670===
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Structural analysis of Bacillus pumilus phenolic acid decarboxylase, a lipocalin-fold enzyme.,Matte A, Grosse S, Bergeron H, Abokitse K, Lau PC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt, 11):1407-14. Epub 2010 Oct 27. PMID:21045284<ref>PMID:21045284</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20112419}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3nad" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20112419 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20112419}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3nad]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_pumilus Bacillus pumilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NAD OCA].
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==Reference==
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<ref group="xtra">PMID:20112419</ref><ref group="xtra">PMID:7684291</ref><ref group="xtra">PMID:11058749</ref><ref group="xtra">PMID:18326577</ref><ref group="xtra">PMID:8534115</ref><references group="xtra"/>
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[[Category: Bacillus pumilus]]
[[Category: Bacillus pumilus]]
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[[Category: Abokitse, K.]]
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[[Category: Large Structures]]
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[[Category: Bergeron, H.]]
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[[Category: Abokitse K]]
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[[Category: Grosse, S.]]
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[[Category: Bergeron H]]
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[[Category: Lau, P C.K.]]
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[[Category: Grosse S]]
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[[Category: Matte, A.]]
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[[Category: Lau PCK]]
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[[Category: Beta barrel]]
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[[Category: Matte A]]
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[[Category: Biocatalysis]]
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[[Category: Decarboxylase]]
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[[Category: Lipocalin]]
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[[Category: Lyase]]
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Current revision

Crystal Structure of Phenolic Acid Decarboxylase from Bacillus pumilus UI-670

PDB ID 3nad

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