This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2f9u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:50, 13 March 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2f9u.png|left|200px]]
 
-
<!--
+
==HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane==
-
The line below this paragraph, containing "STRUCTURE_2f9u", creates the "Structure Box" on the page.
+
<StructureSection load='2f9u' size='340' side='right'caption='[[2f9u]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2f9u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F9U FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NH:1,1-DIMETHYLETHYL+[1-CYCLOHEXYL-2-[3-[[[1-[2-[[2-[[2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO]-2-OXOETHYL]AMINO]-1,2-DIOXOETHYL]PENTYL]AMINO]CARBONYL]-2-AZABICYCLO[2.2.1]HEPTAN-2-YL]-2-OXOETHYL]CARBAMATE'>5NH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_2f9u| PDB=2f9u | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9u OCA], [https://pdbe.org/2f9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f9u RCSB], [https://www.ebi.ac.uk/pdbsum/2f9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f9u ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q91RS4_9HEPC Q91RS4_9HEPC]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/2f9u_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f9u ConSurf].
 +
<div style="clear:both"></div>
-
===HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane===
+
==See Also==
-
 
+
*[[Helicase 3D structures|Helicase 3D structures]]
-
 
+
*[[Virus protease 3D structures|Virus protease 3D structures]]
-
<!--
+
__TOC__
-
The line below this paragraph, {{ABSTRACT_PUBMED_16413182}}, adds the Publication Abstract to the page
+
</StructureSection>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16413182 is the PubMed ID number.
+
[[Category: Hepacivirus C]]
-
-->
+
[[Category: Large Structures]]
-
{{ABSTRACT_PUBMED_16413182}}
+
[[Category: Butkiewicz N]]
-
 
+
[[Category: Girijavallabhan V]]
-
==About this Structure==
+
[[Category: Njoroge FG]]
-
[[2f9u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9U OCA].
+
[[Category: Pichardo J]]
-
 
+
[[Category: Prongay AJ]]
-
==Reference==
+
[[Category: Venkatraman S]]
-
<ref group="xtra">PMID:16413182</ref><ref group="xtra">PMID:8861917</ref><ref group="xtra">PMID:16112862</ref><ref group="xtra">PMID:16078825</ref><ref group="xtra">PMID:16211639</ref><ref group="xtra">PMID:15501035</ref><references group="xtra"/>
+
[[Category: Wu W]]
-
[[Category: Hepatitis c virus]]
+
-
[[Category: Butkiewicz, N.]]
+
-
[[Category: Girijavallabhan, V.]]
+
-
[[Category: Njoroge, F G.]]
+
-
[[Category: Pichardo, J.]]
+
-
[[Category: Prongay, A J.]]
+
-
[[Category: Venkatraman, S.]]
+
-
[[Category: Wu, W.]]
+
-
[[Category: Hcv]]
+
-
[[Category: Hepatitis c protease]]
+
-
[[Category: Ketoamide inhibitor]]
+
-
[[Category: Ns3 protease]]
+
-
[[Category: Viral protein]]
+

Current revision

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane

PDB ID 2f9u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f9u"
Personal tools