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1e0r

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[[Image:1e0r.png|left|200px]]
 
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==Beta-apical domain of thermosome==
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The line below this paragraph, containing "STRUCTURE_1e0r", creates the "Structure Box" on the page.
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<StructureSection load='1e0r' size='340' side='right'caption='[[1e0r]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1e0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E0R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e0r OCA], [https://pdbe.org/1e0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e0r RCSB], [https://www.ebi.ac.uk/pdbsum/1e0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e0r ProSAT]</span></td></tr>
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{{STRUCTURE_1e0r| PDB=1e0r | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THSB_THEAC THSB_THEAC] Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/1e0r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e0r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the beta-apical domain of the thermosome, an archaeal group II chaperonin from Thermoplasma acidophilum, has been determined at 2.8 A resolution. The structure shows an invariant globular core from which a 25 A long protrusion emanates, composed of an elongated alpha-helix (H10) and a long extended stretch consisting of residues GluB245-ThrB253. A comparison with previous apical domain structures reveals a large segmental displacement of the protruding part of helix H10 via the hinge GluB276-ValB278. The region comprising residues GluB245-ThrB253 adopts an extended beta-like conformation rather than the alpha-helix seen in the alpha-apical domain. Consequently, it appears that the protrusions of the apical domains from group II chaperonins might assume a variety of context-dependent conformations during an open, substrate-accepting state of the chaperonin. Sequence variations in the protrusion regions that are found in the eukaryotic TRiC/CCT subunits may provide different structural propensities and hence serve different roles in substrate recognition.
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===BETA-APICAL DOMAIN OF THERMOSOME===
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Crystal structure of the beta-apical domain of the thermosome reveals structural plasticity in the protrusion region.,Bosch G, Baumeister W, Essen LO J Mol Biol. 2000 Aug 4;301(1):19-25. PMID:10926489<ref>PMID:10926489</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1e0r" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10926489}}, adds the Publication Abstract to the page
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*[[Chaperonin 3D structures|Chaperonin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10926489 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10926489}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1e0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0R OCA].
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==Reference==
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<ref group="xtra">PMID:10926489</ref><ref group="xtra">PMID:9546398</ref><ref group="xtra">PMID:9346243</ref><references group="xtra"/>
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[[Category: Thermoplasma acidophilum]]
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[[Category: Baumeister, W.]]
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[[Category: Bosch, G.]]
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[[Category: Essen, L O.]]
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[[Category: Chaperonin]]
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[[Category: Groel]]
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[[Category: Hsp60]]
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[[Category: Tcp1]]
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[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
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[[Category: Thermosome]]
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[[Category: Baumeister W]]
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[[Category: Bosch G]]
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[[Category: Essen L-O]]

Current revision

Beta-apical domain of thermosome

PDB ID 1e0r

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