1zwt

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[[Image:1zwt.png|left|200px]]
 
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==Structure of the globular head domain of the bundlin, BfpA, of the bundle-forming pilus of Enteropathogenic E.coli==
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The line below this paragraph, containing "STRUCTURE_1zwt", creates the "Structure Box" on the page.
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<StructureSection load='1zwt' size='340' side='right'caption='[[1zwt]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O127:H6 Escherichia coli O127:H6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZWT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zwt OCA], [https://pdbe.org/1zwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zwt RCSB], [https://www.ebi.ac.uk/pdbsum/1zwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zwt ProSAT]</span></td></tr>
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{{STRUCTURE_1zwt| PDB=1zwt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BFPA_ECO27 BFPA_ECO27] Major repeating bundle-forming pilus (BFP) subunit. Is required for EPEC localized adherence.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zw/1zwt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zwt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bundle-forming pili (BFP) are essential for the full virulence of enteropathogenic Escherichia coli (EPEC) because they are required for localized adherence to epithelial cells and auto-aggregation. We report the high resolution structure of bundlin, the monomer of BFP, solved by NMR. The structure reveals a new variation in the topology of type IVb pilins with significant differences in the composition and relative orientation of elements of secondary structure. In addition, the structural parameters of native BFP filaments were determined by electron microscopy after negative staining. The solution structure of bundlin was assembled according to these helical parameters to provide a plausible atomic resolution model for the BFP filament. We show that EPEC and Vibriocholerae type IVb pili display distinct differences in their monomer subunits consistent with data showing that bundlin and TcpA cannot complement each other, but assemble into filaments with similar helical organization.
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===Structure of the globular head domain of the bundlin, BfpA, of the bundle-forming pilus of Enteropathogenic E.coli===
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Structure of the bundle-forming pilus from enteropathogenic Escherichia coli.,Ramboarina S, Fernandes PJ, Daniell S, Islam S, Simpson P, Frankel G, Booy F, Donnenberg MS, Matthews S J Biol Chem. 2005 Dec 2;280(48):40252-60. Epub 2005 Sep 19. PMID:16172128<ref>PMID:16172128</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16172128}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zwt" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16172128 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_16172128}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli O127:H6]]
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[[1zwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o127:h6 Escherichia coli o127:h6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWT OCA].
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[[Category: Large Structures]]
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[[Category: Booy F]]
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==Reference==
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[[Category: Daniell S]]
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<ref group="xtra">PMID:16172128</ref><ref group="xtra">PMID:15213452</ref><references group="xtra"/>
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[[Category: Donnenberg MS]]
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[[Category: Escherichia coli o127:h6]]
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[[Category: Fernandes PJ]]
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[[Category: Booy, F.]]
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[[Category: Frankel G]]
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[[Category: Daniell, S.]]
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[[Category: Islam S]]
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[[Category: Donnenberg, M S.]]
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[[Category: Matthews S]]
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[[Category: Fernandes, P J.]]
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[[Category: Ramboarina S]]
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[[Category: Frankel, G.]]
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[[Category: Islam, S.]]
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[[Category: Matthews, S.]]
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[[Category: Ramboarina, S.]]
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[[Category: Alpha-beta fold]]
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[[Category: Beta-sandwich]]
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[[Category: Cell adhesion]]
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[[Category: One disulfide bond]]
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Current revision

Structure of the globular head domain of the bundlin, BfpA, of the bundle-forming pilus of Enteropathogenic E.coli

PDB ID 1zwt

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