2jd4

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[[Image:2jd4.png|left|200px]]
 
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==Mouse laminin alpha1 chain, domains LG4-5==
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The line below this paragraph, containing "STRUCTURE_2jd4", creates the "Structure Box" on the page.
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<StructureSection load='2jd4' size='340' side='right'caption='[[2jd4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jd4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JD4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2jd4| PDB=2jd4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jd4 OCA], [https://pdbe.org/2jd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2jd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jd4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LAMA1_MOUSE LAMA1_MOUSE] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jd/2jd4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jd4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The laminin G-like (LG) domains of laminin-111, a glycoprotein widely expressed during embryogenesis, provide cell anchoring and receptor binding sites that are involved in basement membrane assembly and cell signaling. We now report the crystal structure of the laminin alpha1LG4-5 domains and provide a mutational analysis of heparin, alpha-dystroglycan, and galactosylsulfatide binding. The two domains of alpha1LG4-5 are arranged in a V-shaped fashion similar to that observed with laminin alpha2 LG4-5 but with a substantially different interdomain angle. Recombinant alpha1LG4-5 binding to heparin, alpha-dystroglycan, and sulfatides was dependent upon both shared and unique contributions from basic residues distributed in several clusters on the surface of LG4. For heparin, the greatest contribution was detected from two clusters, 2719RKR and 2791KRK. Binding to alpha-dystroglycan was particularly dependent on basic residues within 2719RKR, 2831RAR, and 2858KDR. Binding to galactosylsulfatide was most affected by mutations in 2831RAR and 2766KGRTK but not in 2719RKR. The combined analysis of structure and activities reveal differences in LG domain interactions that should enable dissection of biological roles of different laminin ligands.
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===MOUSE LAMININ ALPHA1 CHAIN, DOMAINS LG4-5===
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Crystal structure and cell surface anchorage sites of laminin alpha1LG4-5.,Harrison D, Hussain SA, Combs AC, Ervasti JM, Yurchenco PD, Hohenester E J Biol Chem. 2007 Apr 13;282(15):11573-81. Epub 2007 Feb 15. PMID:17307732<ref>PMID:17307732</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2jd4" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17307732}}, adds the Publication Abstract to the page
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*[[Laminin|Laminin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17307732 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17307732}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2jd4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JD4 OCA].
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==Reference==
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<ref group="xtra">PMID:17307732</ref><ref group="xtra">PMID:10747011</ref><ref group="xtra">PMID:15473841</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Combs, A C.]]
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[[Category: Combs AC]]
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[[Category: Ervasti, J M.]]
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[[Category: Ervasti JM]]
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[[Category: Harrison, D.]]
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[[Category: Harrison D]]
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[[Category: Hohenester, E.]]
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[[Category: Hohenester E]]
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[[Category: Hussain, S A.]]
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[[Category: Hussain SA]]
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[[Category: Yurchenco, P D.]]
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[[Category: Yurchenco PD]]
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[[Category: Basement membrane protein]]
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[[Category: Laminin-111]]
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[[Category: Metal binding protein]]
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Current revision

Mouse laminin alpha1 chain, domains LG4-5

PDB ID 2jd4

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