2qzv
From Proteopedia
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| - | [[Image:2qzv.png|left|200px]] | ||
| - | + | ==Draft Crystal Structure of the Vault Shell at 9 Angstroms Resolution== | |
| - | + | <StructureSection load='2qzv' size='340' side='right'caption='[[2qzv]], [[Resolution|resolution]] 9.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2qzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QZV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 9Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qzv OCA], [https://pdbe.org/2qzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qzv RCSB], [https://www.ebi.ac.uk/pdbsum/2qzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qzv ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/MVP_RAT MVP_RAT] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity). | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | < | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/2qzv_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | == | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qzv ConSurf]. |
| - | [[2qzv]] is a 2 chain structure with sequence from [ | + | <div style="clear:both"></div> |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | < | + | [[Category: Large Structures]] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Anderson | + | [[Category: Anderson DH]] |
| - | [[Category: Eisenberg | + | [[Category: Eisenberg D]] |
| - | [[Category: Kickhoefer | + | [[Category: Kickhoefer VA]] |
| - | [[Category: Rome | + | [[Category: Rome LH]] |
| - | [[Category: Sievers | + | [[Category: Sievers SA]] |
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Current revision
Draft Crystal Structure of the Vault Shell at 9 Angstroms Resolution
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