1uw1

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[[Image:1uw1.png|left|200px]]
 
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==A Novel ADP- and Zinc-binding fold from function-directed in vitro evolution==
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The line below this paragraph, containing "STRUCTURE_1uw1", creates the "Structure Box" on the page.
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<StructureSection load='1uw1' size='340' side='right'caption='[[1uw1]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1uw1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UW1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1uw1| PDB=1uw1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw1 OCA], [https://pdbe.org/1uw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uw1 RCSB], [https://www.ebi.ac.uk/pdbsum/1uw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw1 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A great challenge to biologists is to create proteins with novel folds and tailored functions. As an alternative to de novo protein design, we investigated the structure of a randomly generated protein targeted to bind ATP. The crystal structure reveals a novel alpha/beta fold bound to its ligand, representing both the first protein structure derived from in vitro evolution and the first nucleotide-binding protein stabilized by a zinc ion.
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===A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION===
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A novel ADP- and zinc-binding fold from function-directed in vitro evolution.,Lo Surdo P, Walsh MA, Sollazzo M Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384<ref>PMID:15024384</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1uw1" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15024384 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15024384}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1uw1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA].
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[[Category: Synthetic construct]]
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[[Category: Lo Surdo P]]
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==Reference==
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[[Category: Sollazzo M]]
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<ref group="xtra">PMID:15024384</ref><ref group="xtra">PMID:11287961</ref><references group="xtra"/>
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[[Category: Walsh MA]]
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[[Category: Sollazzo, M.]]
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[[Category: Surdo, P Lo.]]
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[[Category: Walsh, M A.]]
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[[Category: Artificial nucleotide binding protein]]
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[[Category: In vitro evolution]]
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[[Category: Nucleotide binding protein]]
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Current revision

A Novel ADP- and Zinc-binding fold from function-directed in vitro evolution

PDB ID 1uw1

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