This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3d8d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3d8d" [edit=sysop:move=sysop])
Current revision (08:23, 20 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3d8d.png|left|200px]]
 
-
<!--
+
==Crystal structure of the human Fe65-PTB1 domain==
-
The line below this paragraph, containing "STRUCTURE_3d8d", creates the "Structure Box" on the page.
+
<StructureSection load='3d8d' size='340' side='right'caption='[[3d8d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3d8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D8D FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-
{{STRUCTURE_3d8d| PDB=3d8d | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d8d OCA], [https://pdbe.org/3d8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d8d RCSB], [https://www.ebi.ac.uk/pdbsum/3d8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d8d ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal structure of the human Fe65-PTB1 domain===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/APBB1_HUMAN APBB1_HUMAN] Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).<ref>PMID:15031292</ref> <ref>PMID:18468999</ref> <ref>PMID:18922798</ref> <ref>PMID:19234442</ref> <ref>PMID:19343227</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_18550529}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 18550529 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/3d8d_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_18550529}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
[[3d8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D8D OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d8d ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:18550529</ref><ref group="xtra">PMID:18453707</ref><references group="xtra"/>
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Radzimanowski, J.]]
+
[[Category: Large Structures]]
-
[[Category: Ravaud, S.]]
+
[[Category: Radzimanowski J]]
-
[[Category: Sinning, I.]]
+
[[Category: Ravaud S]]
-
[[Category: Wild, K.]]
+
[[Category: Sinning I]]
-
[[Category: Alpha-beta structure]]
+
[[Category: Wild K]]
-
[[Category: Alternative splicing]]
+
-
[[Category: Phosphotyrosine binding domain]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Protein binding]]
+

Current revision

Crystal structure of the human Fe65-PTB1 domain

PDB ID 3d8d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3d8d"
Personal tools