2vz8

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[[Image:2vz8.png|left|200px]]
 
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==Crystal Structure of Mammalian Fatty Acid Synthase==
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The line below this paragraph, containing "STRUCTURE_2vz8", creates the "Structure Box" on the page.
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<StructureSection load='2vz8' size='340' side='right'caption='[[2vz8]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vz8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZ8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.219&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vz8 OCA], [https://pdbe.org/2vz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vz8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vz8 ProSAT]</span></td></tr>
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{{STRUCTURE_2vz8| PDB=2vz8 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A5YV76_PIG A5YV76_PIG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vz/2vz8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vz8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mammalian fatty acid synthase is a large multienzyme that catalyzes all steps of fatty acid synthesis. We have determined its crystal structure at 3.2 angstrom resolution covering five catalytic domains, whereas the flexibly tethered terminal acyl carrier protein and thioesterase domains remain unresolved. The structure reveals a complex architecture of alternating linkers and enzymatic domains. Substrate shuttling is facilitated by flexible tethering of the acyl carrier protein domain and by the limited contact between the condensing and modifying portions of the multienzyme, which are mainly connected by linkers rather than direct interaction. The structure identifies two additional nonenzymatic domains: (i) a pseudo-ketoreductase and (ii) a peripheral pseudo-methyltransferase that is probably a remnant of an ancestral methyltransferase domain maintained in some related polyketide synthases. The structural comparison of mammalian fatty acid synthase with modular polyketide synthases shows how their segmental construction allows the variation of domain composition to achieve diverse product synthesis.
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===CRYSTAL STRUCTURE OF MAMMALIAN FATTY ACID SYNTHASE===
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The crystal structure of a mammalian fatty acid synthase.,Maier T, Leibundgut M, Ban N Science. 2008 Sep 5;321(5894):1315-22. PMID:18772430<ref>PMID:18772430</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vz8" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18772430}}, adds the Publication Abstract to the page
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*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18772430 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18772430}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2vz8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ8 OCA].
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==Reference==
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<ref group="xtra">PMID:18772430</ref><ref group="xtra">PMID:16513975</ref><references group="xtra"/>
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[[Category: Fatty-acid synthase]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Ban, N.]]
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[[Category: Ban N]]
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[[Category: Leibundgut, M.]]
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[[Category: Leibundgut M]]
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[[Category: Maier, T.]]
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[[Category: Maier T]]
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[[Category: Fatty acid synthase]]
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[[Category: Fatty acid synthesis]]
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[[Category: Megasynthase]]
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[[Category: Multienzyme]]
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[[Category: Phosphopantetheine]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Mammalian Fatty Acid Synthase

PDB ID 2vz8

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