3a0r

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[[Image:3a0r.png|left|200px]]
 
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==Crystal structure of histidine kinase ThkA (TM1359) in complex with response regulator protein TrrA (TM1360)==
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The line below this paragraph, containing "STRUCTURE_3a0r", creates the "Structure Box" on the page.
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<StructureSection load='3a0r' size='340' side='right'caption='[[3a0r]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A0R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3a0r| PDB=3a0r | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TM_1359 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589]), TM_1360 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a0r OCA], [https://pdbe.org/3a0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a0r RCSB], [https://www.ebi.ac.uk/pdbsum/3a0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a0r ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/3a0r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a0r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We determined the structure of the complex of the sensory histidine kinase (HK) and its cognate response regulator (RR) in the two-component signal transduction system of Thermotoga maritima. This was accomplished by fitting the high-resolution structures of the isolated HK domains and the RR onto the electron density map (3.8 A resolution) of the HK/RR complex crystal. Based on the structural information, we evaluated the roles of both interdomain and intermolecular interactions in the signal transduction of the cytosolic PAS-linked HK and RR system, in particular the O(2)-sensor FixL/FixJ system. The PAS-sensor domain of HK interacts with the catalytic domain of the same polypeptide chain by creating an interdomain beta sheet. The interaction site between HK and RR, which was confirmed by NMR, is suitable for the intermolecular transfer reaction of the phosphoryl group, indicating that the observed interaction is important for the phosphatase activity of HK that dephosphorylates phospho-RR.
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===Crystal structure of histidine kinase ThkA (TM1359) in complex with response regulator protein TrrA (TM1360)===
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Structure of PAS-linked histidine kinase and the response regulator complex.,Yamada S, Sugimoto H, Kobayashi M, Ohno A, Nakamura H, Shiro Y Structure. 2009 Oct 14;17(10):1333-44. PMID:19836334<ref>PMID:19836334</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3a0r" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19836334}}, adds the Publication Abstract to the page
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*[[Response regulator 3D structure|Response regulator 3D structure]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19836334 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19836334}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Atcc 43589]]
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[[3a0r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A0R OCA].
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==Reference==
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<ref group="xtra">PMID:19836334</ref><ref group="xtra">PMID:16890956</ref><references group="xtra"/>
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[[Category: Histidine kinase]]
[[Category: Histidine kinase]]
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[[Category: Thermotoga maritima]]
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[[Category: Large Structures]]
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[[Category: Kobayashi, M.]]
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[[Category: Kobayashi, M]]
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[[Category: Nakamura, H.]]
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[[Category: Nakamura, H]]
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[[Category: Ohno, A.]]
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[[Category: Ohno, A]]
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[[Category: Shiro, Y.]]
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[[Category: Shiro, Y]]
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[[Category: Sugimoto, H.]]
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[[Category: Sugimoto, H]]
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[[Category: Yamada, S.]]
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[[Category: Yamada, S]]
[[Category: Four helix bundle]]
[[Category: Four helix bundle]]
[[Category: Kinase]]
[[Category: Kinase]]

Current revision

Crystal structure of histidine kinase ThkA (TM1359) in complex with response regulator protein TrrA (TM1360)

PDB ID 3a0r

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