2ux8

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[[Image:2ux8.png|left|200px]]
 
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==Crystal Structure of Sphingomonas elodea ATCC 31461 Glucose-1- phosphate uridylyltransferase in Complex with glucose-1-phosphate.==
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The line below this paragraph, containing "STRUCTURE_2ux8", creates the "Structure Box" on the page.
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<StructureSection load='2ux8' size='340' side='right'caption='[[2ux8]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ux8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingomonas_elodea Sphingomonas elodea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UX8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G1P:ALPHA-D-GLUCOSE-1-PHOSPHATE'>G1P</scene></td></tr>
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{{STRUCTURE_2ux8| PDB=2ux8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ux8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ux8 OCA], [https://pdbe.org/2ux8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ux8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ux8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ux8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5FYV5_SPHEL Q5FYV5_SPHEL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ux/2ux8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ux8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Gellan gum is a widely used commercial material, available in many different forms. Its economic importance has led to studies into the biosynthesis of exopolysaccharide gellan gum, which is industrially prepared in high yields using Sphingomonas elodea ATCC 31461. Glucose-1-phosphate uridylyltransferase mediates the reversible conversion of glucose-1-phosphate and UTP into UDP-glucose and pyrophosphate, which is a key step in the biosynthetic pathway of gellan gums. Here we present the X-ray crystal structure of the glucose-1-phosphate uridylyltransferase from S. elodea. The S. elodea enzyme shares strong monomeric similarity with glucose-1-phosphate thymidylyltransferase, several structures of which are known, although the quaternary structures of the active enzymes are rather different. A detailed comparison between S. elodea glucose-1-phosphate uridylyltransferase and available thymidylyltransferases is described and shows remarkable structural similarities, despite the low sequence identities between the two divergent groups of proteins.
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===CRYSTAL STRUCTURE OF SPHINGOMONAS ELODEA ATCC 31461 GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE IN COMPLEX WITH GLUCOSE-1-PHOSPHATE.===
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The complex of Sphingomonas elodea ATCC 31461 glucose-1-phosphate uridylyltransferase with glucose-1-phosphate reveals a novel quaternary structure, unique among nucleoside diphosphate-sugar pyrophosphorylase members.,Aragao D, Fialho AM, Marques AR, Mitchell EP, Sa-Correia I, Frazao C J Bacteriol. 2007 Jun;189(12):4520-8. Epub 2007 Apr 13. PMID:17434970<ref>PMID:17434970</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17434970}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ux8" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17434970 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17434970}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2ux8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingomonas_elodea Sphingomonas elodea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UX8 OCA].
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==Reference==
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<ref group="xtra">PMID:17434970</ref><ref group="xtra">PMID:16946483</ref><references group="xtra"/>
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[[Category: Sphingomonas elodea]]
[[Category: Sphingomonas elodea]]
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[[Category: UTP--glucose-1-phosphate uridylyltransferase]]
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[[Category: Aragao D]]
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[[Category: Aragao, D.]]
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[[Category: Fialho AM]]
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[[Category: Fialho, A M.]]
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[[Category: Frazao C]]
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[[Category: Frazao, C.]]
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[[Category: Marques AR]]
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[[Category: Marques, A R.]]
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[[Category: Mitchell EP]]
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[[Category: Mitchell, E P.]]
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[[Category: Sa-Correia I]]
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[[Category: Sa-Correia, I.]]
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[[Category: Galu pyrophosphorylase]]
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[[Category: Glucose-1-phosphate uridylyltransferase]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Transferase]]
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[[Category: Ugpg]]
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Current revision

Crystal Structure of Sphingomonas elodea ATCC 31461 Glucose-1- phosphate uridylyltransferase in Complex with glucose-1-phosphate.

PDB ID 2ux8

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