1oln

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[[Image:1oln.png|left|200px]]
 
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==Model for thiostrepton antibiotic binding to L11 substrate from 50S ribosomal RNA==
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The line below this paragraph, containing "STRUCTURE_1oln", creates the "Structure Box" on the page.
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<StructureSection load='1oln' size='340' side='right'caption='[[1oln]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1oln]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus] and [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OLN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Solution NMR , Theoretical Model</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB9:(2Z)-2-AMINO-3-SULFANYLPROP-2-ENOIC+ACID'>BB9</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=MH6:3-HYDROXY-2-IMINOPROPANOIC+ACID'>MH6</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=QUA:8-HYDROXY-4-(1-HYDROXYETHYL)QUINOLINE-2-CARBOXYLIC+ACID'>QUA</scene>, <scene name='pdbligand=TS9:(2S,3S,4R)-2-AMINO-3,4-DIHYDROXY-3-METHYLPENTANOIC+ACID'>TS9</scene></td></tr>
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{{STRUCTURE_1oln| PDB=1oln | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oln OCA], [https://pdbe.org/1oln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oln RCSB], [https://www.ebi.ac.uk/pdbsum/1oln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oln ProSAT]</span></td></tr>
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</table>
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===MODEL FOR THIOSTREPTON ANTIBIOTIC BINDING TO L11 SUBSTRATE FROM 50S RIBOSOMAL RNA===
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== Function ==
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[https://www.uniprot.org/uniprot/RL11_THEMA RL11_THEMA] This protein binds directly to 23S ribosomal RNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12954336}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12954336 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ol/1oln_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12954336}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1oln]] is a 3 chain structure of [[Ribosomal protein L11]] with sequence from [http://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus] and [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLN OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oln ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ribosomal protein L11]]
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*[[Ribosomal protein L11 3D structures|Ribosomal protein L11 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:12954336</ref><ref group="xtra">PMID:10338213</ref><ref group="xtra">PMID:10325228</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Streptomyces azureus]]
[[Category: Streptomyces azureus]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Aboul-Ela, F.]]
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[[Category: Aboul-Ela F]]
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[[Category: Klinck, R.]]
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[[Category: Klinck R]]
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[[Category: Lentzen, G.]]
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[[Category: Lentzen G]]
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[[Category: Matassova, N.]]
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[[Category: Matassova N]]
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[[Category: Murchie, A I.H.]]
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[[Category: Murchie AIH]]
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[[Category: 50]]
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[[Category: Antibiotic]]
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[[Category: L11]]
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[[Category: Ribosome]]
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[[Category: Rna]]
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[[Category: Thiazole]]
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[[Category: Thiostrepton]]
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[[Category: Translation inhibition]]
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Current revision

Model for thiostrepton antibiotic binding to L11 substrate from 50S ribosomal RNA

PDB ID 1oln

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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