2bt8

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[[Image:2bt8.png|left|200px]]
 
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==Structure of the C-terminal receptor-binding domain of avian reovirus fibre sigmaC, space group P6322.==
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The line below this paragraph, containing "STRUCTURE_2bt8", creates the "Structure Box" on the page.
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<StructureSection load='2bt8' size='340' side='right'caption='[[2bt8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bt8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_orthoreovirus Avian orthoreovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BT8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bt8 OCA], [https://pdbe.org/2bt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bt8 RCSB], [https://www.ebi.ac.uk/pdbsum/2bt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bt8 ProSAT]</span></td></tr>
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{{STRUCTURE_2bt8| PDB=2bt8 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O12287_9VIRU O12287_9VIRU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/2bt8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bt8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Avian reovirus fibre, a homo-trimer of the sigmaC protein, is responsible for primary host cell attachment. The protein expressed in bacteria forms elongated fibres comprised of a carboxy-terminal globular head domain and a slender shaft, and partial proteolysis yielded a carboxy-terminal protease-stable domain that was amenable to crystallisation. Here, we show that this fragment retains receptor-binding capability and report its structure, solved using two-wavelength anomalous diffraction and refined using data collected from three different crystal forms at 2.1 angstroms, 2.35 angstroms and 3.0 angstroms resolution. The carboxy-terminal globular domain has a beta-barrel fold with the same overall topology as the mammalian reovirus fibre (sigma1). However, the monomers of the sigmaC trimer show a more splayed-out arrangement than in the sigma1 structure. Also resolved are two triple beta-spiral repeats of the shaft or stalk domain. The presence in the sequence of heptad repeats amino-terminal to these triple beta-spiral repeats suggests that the unresolved portion of the shaft domain contains a triple alpha-helical coiled-coil structure. Implications for the function and stability of the sigmaC protein are discussed.
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===STRUCTURE OF THE C-TERMINAL RECEPTOR-BINDING DOMAIN OF AVIAN REOVIRUS FIBRE SIGMAC, SPACE GROUP P6322.===
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Structure of the carboxy-terminal receptor-binding domain of avian reovirus fibre sigmaC.,Guardado Calvo P, Fox GC, Hermo Parrado XL, Llamas-Saiz AL, Costas C, Martinez-Costas J, Benavente J, van Raaij MJ J Mol Biol. 2005 Nov 18;354(1):137-49. Epub 2005 Sep 30. PMID:16236316<ref>PMID:16236316</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2bt8" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16236316}}, adds the Publication Abstract to the page
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16236316 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16236316}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2bt8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Avian_orthoreovirus Avian orthoreovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BT8 OCA].
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==Reference==
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<ref group="xtra">PMID:16236316</ref><ref group="xtra">PMID:11782420</ref><ref group="xtra">PMID:8985323</ref><ref group="xtra">PMID:10964779</ref><ref group="xtra">PMID:11883183</ref><ref group="xtra">PMID:11752709</ref><references group="xtra"/>
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[[Category: Avian orthoreovirus]]
[[Category: Avian orthoreovirus]]
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[[Category: Calvo, P Guardado.]]
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[[Category: Large Structures]]
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[[Category: Fox, G C.]]
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[[Category: Fox GC]]
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[[Category: Llamas-Saiz, A L.]]
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[[Category: Guardado Calvo P]]
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[[Category: Parrado, X L.Hermo.]]
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[[Category: Hermo Parrado XL]]
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[[Category: Raaij, M J.Van.]]
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[[Category: Llamas-Saiz AL]]
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[[Category: Beta-barrel]]
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[[Category: Van Raaij MJ]]
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[[Category: Orthoreovirus]]
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[[Category: Triple beta-spiral]]
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[[Category: Viral protein]]
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Current revision

Structure of the C-terminal receptor-binding domain of avian reovirus fibre sigmaC, space group P6322.

PDB ID 2bt8

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