This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2b1o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2b1o" [edit=sysop:move=sysop])
Current revision (11:19, 22 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2b1o.png|left|200px]]
 
-
<!--
+
==Solution Structure of Ca2+-bound DdCAD-1==
-
The line below this paragraph, containing "STRUCTURE_2b1o", creates the "Structure Box" on the page.
+
<StructureSection load='2b1o' size='340' side='right'caption='[[2b1o]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2b1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B1O FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
{{STRUCTURE_2b1o| PDB=2b1o | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b1o OCA], [https://pdbe.org/2b1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b1o RCSB], [https://www.ebi.ac.uk/pdbsum/2b1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b1o ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CAD1_DICDI CAD1_DICDI] Mediates calcium-dependent cell-cell adhesion during the early stage of development.<ref>PMID:8663243</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b1/2b1o_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b1o ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
DdCAD-1 is a novel Ca(2+)-dependent cell adhesion molecule that lacks a hydrophobic signal peptide and a transmembrane domain. DdCAD-1 is expressed by the social amoeba Dictyostelium discoideum at the onset of development. It is synthesized as a soluble protein and then transported to the plasma membrane by contractile vacuoles. Here we describe the novel features of the solution structures of Ca(2+)-free and Ca(2+)-bound monomeric DdCAD-1. DdCAD-1 contains two beta-sandwich domains, belonging to the betagamma-crystallin and immunoglobulin fold classes, respectively. Whereas the N-terminal domain has a major role in homophilic binding, the C-terminal domain tethers the protein to the cell membrane. From structural and mutational analyses, we propose a model for the Ca(2+)-bound DdCAD-1 dimer as a basis for understanding DdCAD-1-mediated cell-cell adhesion at the molecular level. Our results provide new insights into Ca(2+)-dependent mechanisms for cell-cell adhesion.
-
===Solution Structure of Ca2+-bound DdCAD-1===
+
Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion.,Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:17057715<ref>PMID:17057715</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_17057715}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2b1o" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 17057715 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_17057715}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
[[2b1o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1O OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:17057715</ref><ref group="xtra">PMID:15756470</ref><references group="xtra"/>
+
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
-
[[Category: Huang, H B.]]
+
[[Category: Large Structures]]
-
[[Category: Lin, Z.]]
+
[[Category: Huang HB]]
-
[[Category: Siu, C H.]]
+
[[Category: Lin Z]]
-
[[Category: Sriskanthadevan, S.]]
+
[[Category: Siu CH]]
-
[[Category: Yang, D W.]]
+
[[Category: Sriskanthadevan S]]
-
[[Category: Calcium]]
+
[[Category: Yang DW]]
-
[[Category: Cell adherison]]
+
-
[[Category: Cell adhesion]]
+
-
[[Category: Ddcad-1]]
+
-
[[Category: Nmr]]
+

Current revision

Solution Structure of Ca2+-bound DdCAD-1

PDB ID 2b1o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b1o"
Personal tools