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2isl

From Proteopedia

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[[Image:2isl.png|left|200px]]
 
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==BluB bound to reduced flavin (FMNH2) and molecular oxygen. (clear crystal form)==
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The line below this paragraph, containing "STRUCTURE_2isl", creates the "Structure Box" on the page.
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<StructureSection load='2isl' size='340' side='right'caption='[[2isl]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2isl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Sinorhizobium_meliloti Sinorhizobium meliloti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ISL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ISL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FNR:1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL'>FNR</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
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{{STRUCTURE_2isl| PDB=2isl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2isl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2isl OCA], [https://pdbe.org/2isl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2isl RCSB], [https://www.ebi.ac.uk/pdbsum/2isl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2isl ProSAT]</span></td></tr>
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</table>
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===BluB bound to reduced flavin (FMNH2) and molecular oxygen. (clear crystal form)===
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== Function ==
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[https://www.uniprot.org/uniprot/BLUB_RHIME BLUB_RHIME] Involved in the biosynthesis of cobalamin (vitamin B12). Catalyzes the oxidative fragmentation and contraction of the isoalloxazine heterocycle and the cleavage of the ribityl tail of FMN(2) to form 5,6-dimethylbenzimidazole (DMB) and D-erythrose 4-phosphate (E4P). NAD(P)H is only required initially to reduce FMN and oxygen drives the oxidative fragmentation.<ref>PMID:16537439</ref> <ref>PMID:17377583</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_17377583}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17377583 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/2isl_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17377583}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2isl]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sinorhizobium_meliloti Sinorhizobium meliloti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ISL OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2isl ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:17377583</ref><ref group="xtra">PMID:16537439</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Sinorhizobium meliloti]]
[[Category: Sinorhizobium meliloti]]
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[[Category: Howard-Jones, A R.]]
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[[Category: Howard-Jones AR]]
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[[Category: Larsen, N A.]]
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[[Category: Larsen NA]]
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[[Category: Taga, M E.]]
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[[Category: Taga ME]]
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[[Category: Walker, G C.]]
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[[Category: Walker GC]]
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[[Category: Walsh, C T.]]
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[[Category: Walsh CT]]
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[[Category: Flavin]]
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[[Category: Flavin destructase]]
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[[Category: Flavoprotein]]
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[[Category: Molecular oxygen]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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Current revision

BluB bound to reduced flavin (FMNH2) and molecular oxygen. (clear crystal form)

PDB ID 2isl

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