3kxs

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[[Image:3kxs.png|left|200px]]
 
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==Crystal structure of HBV capsid mutant dimer (oxy form), strain adyw==
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The line below this paragraph, containing "STRUCTURE_3kxs", creates the "Structure Box" on the page.
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<StructureSection load='3kxs' size='340' side='right'caption='[[3kxs]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kxs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus_subtype_adyw Hepatitis B virus subtype adyw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KXS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxs OCA], [https://pdbe.org/3kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kxs RCSB], [https://www.ebi.ac.uk/pdbsum/3kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kxs ProSAT]</span></td></tr>
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{{STRUCTURE_3kxs| PDB=3kxs | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_HBVD1 CAPSD_HBVD1] Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).<ref>PMID:7711014</ref> Encapsidates hepatitis delta genome (By similarity).<ref>PMID:7711014</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/3kxs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kxs ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In infected cells, virus components must be organized at the right place and time to ensure assembly of infectious virions. From a different perspective, assembly must be prevented until all components are available. Hypothetically, this can be achieved by allosterically controlling assembly. Consistent with this hypothesis, here we show that the structure of the hepatitis B virus (HBV) core protein dimer, which can spontaneously self-assemble, is incompatible with capsid assembly. Systematic differences between core protein dimer and capsid conformations demonstrate linkage between the intradimer interface and interdimer contact surface. These structures also provide explanations for the capsid-dimer selectivity of some antibodies and the activities of assembly effectors. Solution studies suggest that the assembly-inactive state is more accurately an ensemble of conformations. Simulations show that allostery supports controlled assembly and results in capsids that are resistant to dissociation. We propose that allostery, as demonstrated in HBV, is common to most self-assembling viruses.
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===Crystal structure of HBV capsid mutant dimer (oxy form), strain adyw===
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Conformational changes in the hepatitis B virus core protein are consistent with a role for allostery in virus assembly.,Packianathan C, Katen SP, Dann CE 3rd, Zlotnick A J Virol. 2010 Feb;84(3):1607-15. Epub 2009 Nov 25. PMID:19939922<ref>PMID:19939922</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3kxs" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19939922}}, adds the Publication Abstract to the page
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19939922 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19939922}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Hepatitis B virus subtype adyw]]
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[[3kxs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus_subtype_adyw Hepatitis b virus subtype adyw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXS OCA].
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[[Category: Large Structures]]
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[[Category: Katen SP]]
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==Reference==
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[[Category: Packianathan C]]
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<ref group="xtra">PMID:19939922</ref><ref group="xtra">PMID:19196007</ref><references group="xtra"/>
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[[Category: Zlotnick A]]
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[[Category: Hepatitis b virus subtype adyw]]
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[[Category: Katen, S P.]]
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[[Category: Packianathan, C.]]
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[[Category: Zlotnick, A.]]
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[[Category: Capsid]]
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[[Category: Capsid protein]]
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[[Category: Core protein]]
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[[Category: Dimer]]
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[[Category: Dna-binding]]
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[[Category: Four helix bundle]]
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[[Category: Hepadnavirus]]
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[[Category: Host cytoplasm]]
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[[Category: Host-virus interaction]]
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[[Category: Icosahedral]]
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[[Category: Phosphoprotein]]
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[[Category: Rna-binding]]
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[[Category: Virion]]
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Current revision

Crystal structure of HBV capsid mutant dimer (oxy form), strain adyw

PDB ID 3kxs

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