1wze

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[[Image:1wze.png|left|200px]]
 
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==Structural basis for alteration of cofactor specificity of Malate dehydrogenase from Thermus flavus==
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The line below this paragraph, containing "STRUCTURE_1wze", creates the "Structure Box" on the page.
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<StructureSection load='1wze' size='340' side='right'caption='[[1wze]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wze]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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{{STRUCTURE_1wze| PDB=1wze | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wze OCA], [https://pdbe.org/1wze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wze RCSB], [https://www.ebi.ac.uk/pdbsum/1wze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wze ProSAT]</span></td></tr>
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</table>
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===Structural basis for alteration of cofactor specificity of Malate dehydrogenase from Thermus flavus===
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== Function ==
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[https://www.uniprot.org/uniprot/MDH_THETH MDH_THETH] Catalyzes the reversible oxidation of malate to oxaloacetate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_8471603}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 8471603 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wze_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_8471603}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1wze]] is a 2 chain structure of [[Malate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZE OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wze ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Malate dehydrogenase]]
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*[[Malate Dehydrogenase 3D structures|Malate Dehydrogenase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:8471603</ref><ref group="xtra">PMID:1920425</ref><ref group="xtra">PMID:2775751</ref><ref group="xtra">PMID:3771528</ref><ref group="xtra">PMID:6848515</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Malate dehydrogenase]]
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[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Fushinobu, S.]]
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[[Category: Fushinobu S]]
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[[Category: Kuzuyama, T.]]
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[[Category: Kuzuyama T]]
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[[Category: Nishiyama, M.]]
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[[Category: Nishiyama M]]
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[[Category: Tomita, T.]]
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[[Category: Tomita T]]
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[[Category: Oxidoreductase]]
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[[Category: Protein-nadh complex]]
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[[Category: Seven amino acid residues mutant]]
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Current revision

Structural basis for alteration of cofactor specificity of Malate dehydrogenase from Thermus flavus

PDB ID 1wze

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