2bs2

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[[Image:2bs2.png|left|200px]]
 
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==QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES==
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The line below this paragraph, containing "STRUCTURE_2bs2", creates the "Structure Box" on the page.
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<StructureSection load='2bs2' size='340' side='right'caption='[[2bs2]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bs2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Wolinella_succinogenes Wolinella succinogenes]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1qla 1qla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BS2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=FUM:FUMARIC+ACID'>FUM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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{{STRUCTURE_2bs2| PDB=2bs2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bs2 OCA], [https://pdbe.org/2bs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bs2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bs2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FRDA_WOLSU FRDA_WOLSU] The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bs/2bs2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bs2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Membrane protein complexes can support both the generation and utilisation of a transmembrane electrochemical proton potential ('proton-motive force'), either by transmembrane electron transfer coupled to protolytic reactions on opposite sides of the membrane or by transmembrane proton transfer. Here we provide the first evidence that both of these mechanisms are combined in the case of a specific respiratory membrane protein complex, the dihaem-containing quinol:fumarate reductase (QFR) of Wolinella succinogenes, so as to facilitate transmembrane electron transfer by transmembrane proton transfer. We also demonstrate the non-functionality of this novel transmembrane proton transfer pathway ('E-pathway') in a variant QFR where a key glutamate residue has been replaced. The 'E-pathway', discussed on the basis of the 1.78-Angstrom-resolution crystal structure of QFR, can be concluded to be essential also for the viability of pathogenic varepsilon-proteobacteria such as Helicobacter pylori and is possibly relevant to proton transfer in other dihaem-containing membrane proteins, performing very different physiological functions.
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===QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES===
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Evidence for transmembrane proton transfer in a dihaem-containing membrane protein complex.,Madej MG, Nasiri HR, Hilgendorff NS, Schwalbe H, Lancaster CR EMBO J. 2006 Oct 18;25(20):4963-70. Epub 2006 Oct 5. PMID:17024183<ref>PMID:17024183</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17024183}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2bs2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17024183 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17024183}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2bs2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Wolinella_succinogenes Wolinella succinogenes]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1qla 1qla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BS2 OCA].
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==Reference==
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<ref group="xtra">PMID:17024183</ref><ref group="xtra">PMID:12409197</ref><ref group="xtra">PMID:11248702</ref><ref group="xtra">PMID:11186225</ref><ref group="xtra">PMID:10586875</ref><references group="xtra"/>
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[[Category: Succinate dehydrogenase]]
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[[Category: Wolinella succinogenes]]
[[Category: Wolinella succinogenes]]
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[[Category: Lancaster, C R.D.]]
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[[Category: Lancaster CRD]]
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[[Category: 2fe-2]]
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[[Category: 3fe-4]]
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[[Category: 4fe-4]]
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[[Category: Citric acid cycle]]
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[[Category: Dihaem cytochrome b]]
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[[Category: Electron transport]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Fumarate reductase]]
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[[Category: Heme]]
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[[Category: Ion-sulphur protein]]
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[[Category: Iron]]
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[[Category: Iron-sulfur]]
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[[Category: Metal-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Respiratory chain]]
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[[Category: Succinate dehydrogenase]]
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[[Category: Transmembrane]]
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[[Category: Tricarboxylic acid cycle]]
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Current revision

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QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES

PDB ID 2bs2

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