2gek

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[[Image:2gek.png|left|200px]]
 
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==Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP==
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The line below this paragraph, containing "STRUCTURE_2gek", creates the "Structure Box" on the page.
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<StructureSection load='2gek' size='340' side='right'caption='[[2gek]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GEK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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{{STRUCTURE_2gek| PDB=2gek | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gek OCA], [https://pdbe.org/2gek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gek RCSB], [https://www.ebi.ac.uk/pdbsum/2gek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gek ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP===
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== Function ==
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[https://www.uniprot.org/uniprot/PIMA_MYCS2 PIMA_MYCS2] Catalyzes the addition of a mannose residue from GDP-D-mannose to the position 2 of a phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Contrary to PimB, the mannosyltransferase PimA is unable to transfer a mannose residue to the position 6 of the phosphatidyl-myo-inositola of PIM1.<ref>PMID:12068013</ref> <ref>PMID:19638342</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17510062 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ge/2gek_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17510062}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2gek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEK OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gek ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:17510062</ref><ref group="xtra">PMID:16511084</ref><ref group="xtra">PMID:12068013</ref><ref group="xtra">PMID:15228522</ref><ref group="xtra">PMID:12765785</ref><ref group="xtra">PMID:12691742</ref><references group="xtra"/>
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<references/>
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[[Category: Mycobacterium smegmatis str. mc2 155]]
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__TOC__
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[[Category: Alzari, P M.]]
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</StructureSection>
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[[Category: Buschiazzo, A.]]
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[[Category: Large Structures]]
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[[Category: Guerin, M E.]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Jackson, M.]]
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[[Category: Alzari PM]]
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[[Category: Kordulakova, J.]]
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[[Category: Buschiazzo A]]
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[[Category: Binary complex]]
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[[Category: Guerin ME]]
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[[Category: Gt4 glycosyltransferase]]
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[[Category: Jackson M]]
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[[Category: Mannosyltransferase]]
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[[Category: Kordulakova J]]
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[[Category: Rossmann fold]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP

PDB ID 2gek

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