2wsu

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[[Image:2wsu.png|left|200px]]
 
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==Galectin domain of porcine adenovirus type 4 NADC-1 isolate fibre==
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The line below this paragraph, containing "STRUCTURE_2wsu", creates the "Structure Box" on the page.
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<StructureSection load='2wsu' size='340' side='right'caption='[[2wsu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wsu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_adenovirus_4 Porcine adenovirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WSU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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{{STRUCTURE_2wsu| PDB=2wsu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsu OCA], [https://pdbe.org/2wsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wsu RCSB], [https://www.ebi.ac.uk/pdbsum/2wsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q83467_ADEP4 Q83467_ADEP4]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/2wsu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wsu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Adenovirus isolate NADC-1, a strain of porcine adenovirus type 4, has a fiber containing an N-terminal virus attachment region, shaft and head domains, and a C-terminal galectin domain connected to the head by an RGD-containing sequence. The crystal structure of the head domain is similar to previously solved adenovirus fiber head domains, but specific residues for binding the coxsackievirus and adenovirus receptor (CAR), CD46, or sialic acid are not conserved. The structure of the galectin domain reveals an interaction interface between its two carbohydrate recognition domains, locating both sugar binding sites face to face. Sequence evidence suggests other tandem-repeat galectins have the same arrangement. We show that the galectin domain binds carbohydrates containing lactose and N-acetyl-lactosamine units, and we present structures of the galectin domain with lactose, N-acetyl-lactosamine, 3-aminopropyl-lacto-N-neotetraose, and 2-aminoethyl-tri(N-acetyl-lactosamine), confirming the domain as a bona fide galectin domain.
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===GALECTIN DOMAIN OF PORCINE ADENOVIRUS TYPE 4 NADC-1 ISOLATE FIBRE===
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Crystallographic structure of porcine adenovirus type 4 fiber head and galectin domains.,Guardado-Calvo P, Munoz EM, Llamas-Saiz AL, Fox GC, Kahn R, Curiel DT, Glasgow JN, van Raaij MJ J Virol. 2010 Oct;84(20):10558-68. Epub 2010 Aug 4. PMID:20686025<ref>PMID:20686025</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20686025}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wsu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20686025 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20686025}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2wsu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Porcine_adenovirus_4 Porcine adenovirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSU OCA].
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==Reference==
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<ref group="xtra">PMID:20686025</ref><ref group="xtra">PMID:8837892</ref><ref group="xtra">PMID:18756624</ref><references group="xtra"/>
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[[Category: Porcine adenovirus 4]]
[[Category: Porcine adenovirus 4]]
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[[Category: Fox, G C.]]
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[[Category: Fox GC]]
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[[Category: Glasgow, J N.]]
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[[Category: Glasgow JN]]
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[[Category: Guardado-Calvo, P.]]
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[[Category: Guardado-Calvo P]]
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[[Category: Llamas-Saiz, A L.]]
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[[Category: Llamas-Saiz AL]]
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[[Category: Munoz, E M.]]
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[[Category: Munoz EM]]
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[[Category: Raaij, M J.Van.]]
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[[Category: Van Raaij MJ]]
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[[Category: Carbohydrate recognition domain]]
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[[Category: Tandem-repeat-type]]
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[[Category: Viral protein]]
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Current revision

Galectin domain of porcine adenovirus type 4 NADC-1 isolate fibre

PDB ID 2wsu

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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