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2czu

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[[Image:2czu.png|left|200px]]
 
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==lipocalin-type prostaglandin D synthase==
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The line below this paragraph, containing "STRUCTURE_2czu", creates the "Structure Box" on the page.
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<StructureSection load='2czu' size='340' side='right'caption='[[2czu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2czu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2czu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2czu OCA], [https://pdbe.org/2czu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2czu RCSB], [https://www.ebi.ac.uk/pdbsum/2czu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2czu ProSAT], [https://www.topsan.org/Proteins/RSGI/2czu TOPSAN]</span></td></tr>
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{{STRUCTURE_2czu| PDB=2czu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTGDS_MOUSE PTGDS_MOUSE] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:8922532</ref> <ref>PMID:9892701</ref> <ref>PMID:10781097</ref> <ref>PMID:11751991</ref> <ref>PMID:12077186</ref> <ref>PMID:17715133</ref> <ref>PMID:19546224</ref> <ref>PMID:19833210</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/2czu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2czu ConSurf].
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<div style="clear:both"></div>
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===lipocalin-type prostaglandin D synthase===
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==See Also==
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*[[Prostaglandin D synthase|Prostaglandin D synthase]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19546224}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19546224 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_19546224}}
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==About this Structure==
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[[2czu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZU OCA].
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==Reference==
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<ref group="xtra">PMID:19546224</ref><ref group="xtra">PMID:12761195</ref><ref group="xtra">PMID:9892701</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Prostaglandin-D synthase]]
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[[Category: Ago H]]
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[[Category: Ago, H.]]
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[[Category: Aritake K]]
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[[Category: Aritake, K.]]
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[[Category: Hayaishi O]]
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[[Category: Hayaishi, O.]]
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[[Category: Inoue T]]
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[[Category: Inoue, T.]]
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[[Category: Irikura D]]
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[[Category: Irikura, D.]]
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[[Category: Kumasaka T]]
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[[Category: Kumasaka, T.]]
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[[Category: Miyano M]]
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[[Category: Miyano, M.]]
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[[Category: Urade Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yamamoto M]]
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[[Category: Urade, Y.]]
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[[Category: Yamamoto, M.]]
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[[Category: Isomerase]]
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[[Category: Lipocalin]]
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[[Category: Lpgds_p212121 native]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

lipocalin-type prostaglandin D synthase

PDB ID 2czu

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