2ze0

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[[Image:2ze0.png|left|200px]]
 
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==Alpha-glucosidase GSJ==
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The line below this paragraph, containing "STRUCTURE_2ze0", creates the "Structure Box" on the page.
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<StructureSection load='2ze0' size='340' side='right'caption='[[2ze0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ze0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_sp._HTA-462 Geobacillus sp. HTA-462]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZE0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2ze0| PDB=2ze0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ze0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ze0 OCA], [https://pdbe.org/2ze0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ze0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ze0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ze0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q33E90_9BACI Q33E90_9BACI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ze/2ze0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ze0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the GH13 alpha-glucosidase (GSJ) from deep-sea bacterium Geobacillus sp. strain HTA-462 was determined to a 2.0 A resolution. Comparisons of the GSJ structure with that of other GH13 enzymes with different catalytic activities revealed that the catalytic cleft of GSJ was widely opened when compared with the homologues. The wide opening of the catalytic cleft originated from conformational changes of active site residues and disorder of the regions close to the catalytic center. This structural feature of GSJ would explain the ability of this enzyme to accept a wide variety of nonsugar molecules as acceptors in the transglycosylation reaction.
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===Alpha-glucosidase GSJ===
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Crystal structure of GH13 alpha-glucosidase GSJ from one of the deepest sea bacteria.,Shirai T, Hung VS, Morinaka K, Kobayashi T, Ito S Proteins. 2008 Oct;73(1):126-33. PMID:18398906<ref>PMID:18398906</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ze0" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18398906}}, adds the Publication Abstract to the page
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*[[Alpha-glucosidase 3D structures|Alpha-glucosidase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18398906 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18398906}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Geobacillus sp. HTA-462]]
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[[2ze0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZE0 OCA].
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[[Category: Large Structures]]
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[[Category: Hung VS]]
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==Reference==
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[[Category: Ito S]]
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<ref group="xtra">PMID:18398906</ref><ref group="xtra">PMID:12832785</ref><references group="xtra"/>
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[[Category: Kobayashi T]]
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[[Category: Alpha-glucosidase]]
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[[Category: Morinaka K]]
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[[Category: Bacteria]]
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[[Category: Shirai T]]
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[[Category: Hung, V S.]]
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[[Category: Ito, S.]]
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[[Category: Kobayashi, T.]]
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[[Category: Morinaka, K.]]
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[[Category: Shirai, T.]]
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[[Category: Extremophile]]
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[[Category: Glucoside hydrolase]]
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[[Category: Tim barrel]]
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Current revision

Alpha-glucosidase GSJ

PDB ID 2ze0

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