2zlu

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[[Image:2zlu.png|left|200px]]
 
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==Horse methemoglobin high salt, pH 7.0 (88% relative humidity)==
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The line below this paragraph, containing "STRUCTURE_2zlu", creates the "Structure Box" on the page.
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<StructureSection load='2zlu' size='340' side='right'caption='[[2zlu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zlu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZLU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_2zlu| PDB=2zlu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zlu OCA], [https://pdbe.org/2zlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zlu RCSB], [https://www.ebi.ac.uk/pdbsum/2zlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zlu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HBA_HORSE HBA_HORSE] Involved in oxygen transport from the lung to the various peripheral tissues.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zl/2zlu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zlu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of high-salt horse methaemoglobin has been determined at environmental relative humidities (r.h.) of 88, 79, 75 and 66%. The molecule is in the R state in the native and the r.h. 88% crystals. At r.h. 79%, the water content of the crystal is reduced and the molecule appears to move towards the R2 state. The crystals undergo a water-mediated transformation involving a doubling of one of the unit-cell parameters and an increase in water content when the environmental humidity is further reduced to r.h. 75%. The water content is now similar to that in the native crystals and the molecules are in the R state. The crystal structure at r.h. 66% is similar, but not identical, to that at r.h. 75%, but the solvent content is substantially reduced and the molecules have a quaternary structure that is in between those corresponding to the R and R2 states. Thus, variation in hydration leads to variation in the quaternary structure. Furthermore, partial dehydration appears to shift the structure from the R state to the R2 state. This observation is in agreement with the earlier conclusion that the changes in protein structure that accompany partial dehydration are similar to those that occur during protein action.
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===Horse methemoglobin high salt, pH 7.0 (88% relative humidity)===
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Water-mediated variability in the structure of relaxed-state haemoglobin.,Kaushal PS, Sankaranarayanan R, Vijayan M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt, 6):463-9. Epub 2008 May 17. PMID:18540052<ref>PMID:18540052</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18540052}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2zlu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18540052 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18540052}}
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==About this Structure==
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[[2zlu]] is a 2 chain structure of [[Hemoglobin]] with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZLU OCA].
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==See Also==
==See Also==
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*[[Hemoglobin]]
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:18540052</ref><ref group="xtra">PMID:15887226</ref><ref group="xtra">PMID:12077435</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Equus caballus]]
[[Category: Equus caballus]]
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[[Category: Kaushal, P S.]]
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[[Category: Large Structures]]
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[[Category: Sankaranarayanan, R.]]
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[[Category: Kaushal PS]]
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[[Category: Vijayan, M.]]
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[[Category: Sankaranarayanan R]]
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[[Category: Allosteric transition]]
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[[Category: Vijayan M]]
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[[Category: Heme]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Oxygen storage]]
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[[Category: Oxygen transport]]
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[[Category: Polymorphism]]
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[[Category: Protein hydration]]
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[[Category: Solvent content and crystal structure]]
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[[Category: Transport]]
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[[Category: Variability in quaternary structure]]
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[[Category: Water-mediated transformation]]
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Current revision

Horse methemoglobin high salt, pH 7.0 (88% relative humidity)

PDB ID 2zlu

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