1tu5

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[[Image:1tu5.png|left|200px]]
 
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==Crystal structure of bovine plasma copper-containing amine oxidase==
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The line below this paragraph, containing "STRUCTURE_1tu5", creates the "Structure Box" on the page.
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<StructureSection load='1tu5' size='340' side='right'caption='[[1tu5]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tu5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TU5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene>, <scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene></td></tr>
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{{STRUCTURE_1tu5| PDB=1tu5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tu5 OCA], [https://pdbe.org/1tu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tu5 RCSB], [https://www.ebi.ac.uk/pdbsum/1tu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tu5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOCX_BOVIN AOCX_BOVIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tu5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tu5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Copper-containing amine oxidase extracted from bovine serum (BSAO) was crystallized and its three-dimensional structure at 2.37A resolution is described. The biological unit of BSAO is a homodimer, formed by two monomers related to each other by a non-crystallographic 2-fold axis. Each monomer is composed of three domains, similar to those of other amine oxidases from lower species. The two monomers are structurally equivalent, despite some minor differences at the two active sites. A large funnel allows access of substrates to the active-site; another cavity, accessible to the solvent, is also present between the two monomers; this second cavity could allow the entrance of molecular oxygen necessary for the oxidative reaction. Some sugar residues, bound to Asn, were still present and visible in the electron density map, in spite of the exhaustive deglycosylation necessary to grow the crystals. The comparison of the BSAO structure with those of other resolved AO structures shows strong dissimilarities in the architecture and charge distribution of the cavities leading to the active-site, possibly explaining the differences in substrate specificity.
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===Crystal structure of bovine plasma copper-containing amine oxidase===
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Crystal structure of amine oxidase from bovine serum.,Lunelli M, Di Paolo ML, Biadene M, Calderone V, Battistutta R, Scarpa M, Rigo A, Zanotti G J Mol Biol. 2005 Mar 4;346(4):991-1004. Epub 2005 Jan 25. PMID:15701511<ref>PMID:15701511</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1tu5" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15701511}}, adds the Publication Abstract to the page
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*[[Copper amine oxidase 3D structures|Copper amine oxidase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15701511 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15701511}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1tu5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TU5 OCA].
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==Reference==
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<ref group="xtra">PMID:15701511</ref><ref group="xtra">PMID:12657794</ref><ref group="xtra">PMID:8591022</ref><ref group="xtra">PMID:8805580</ref><ref group="xtra">PMID:14690425</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Oxidoreductase]]
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[[Category: Large Structures]]
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[[Category: Battistutta, R.]]
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[[Category: Battistutta R]]
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[[Category: Biadene, M.]]
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[[Category: Biadene M]]
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[[Category: Calderone, V.]]
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[[Category: Calderone V]]
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[[Category: Lunelli, M.]]
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[[Category: Di Paolo ML]]
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[[Category: Paolo, M L.Di.]]
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[[Category: Lunelli M]]
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[[Category: Rigo, A.]]
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[[Category: Rigo A]]
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[[Category: Scarpa, M.]]
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[[Category: Scarpa M]]
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[[Category: Zanotti, G.]]
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[[Category: Zanotti G]]
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[[Category: Amine oxidase]]
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[[Category: Copper]]
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[[Category: Oxidoreductase]]
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[[Category: Quinoenzyme]]
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[[Category: Tpq]]
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Current revision

Crystal structure of bovine plasma copper-containing amine oxidase

PDB ID 1tu5

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