2bf9

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[[Image:2bf9.png|left|200px]]
 
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==Anisotropic refinement of avian (turkey) pancreatic polypeptide at 0. 99 Angstroms resolution.==
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The line below this paragraph, containing "STRUCTURE_2bf9", creates the "Structure Box" on the page.
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<StructureSection load='2bf9' size='340' side='right'caption='[[2bf9]], [[Resolution|resolution]] 0.99&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bf9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BF9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYC:L-TYROSINAMIDE'>TYC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2bf9| PDB=2bf9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bf9 OCA], [https://pdbe.org/2bf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bf9 RCSB], [https://www.ebi.ac.uk/pdbsum/2bf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bf9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAHO_MELGA PAHO_MELGA] Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/2bf9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bf9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A pancreatic polypeptide with some hormonal properties has been purified from chicken and turkey pancreas using acid-ethanol extraction, gel filtration and anion-exchange chromatography. The material has been crystallised. The crystals are monoclinic with space group C2. Preliminary isomorphous replacement experiments have so far provided a single-site derivative with Hg(NO3)2. A low-resolution electron density map phased with this derivative using anomalous scattering considered together with Patterson function calculations suggest that the molecules are partly helical and are arranged as a compact dimer about the crystallographic two-fold axis. The structure and association of these molecules are compared with those of insulin and glucagon, pancreatic protein and polypeptide hormones respectively, which have been studied in great detail.
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===ANISOTROPIC REFINEMENT OF AVIAN (TURKEY) PANCREATIC POLYPEPTIDE AT 0.99 ANGSTROMS RESOLUTION.===
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Purification, crystallisation and preliminary X-ray studies on avian pancreatic polypeptide.,Wood SP, Pitts JE, Blundell TL, Tickle IJ, Jenkins JA Eur J Biochem. 1977 Aug 15;78(1):119-26. PMID:000913391<ref>PMID:000913391</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[2bf9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BF9 OCA].
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<div class="pdbe-citations 2bf9" style="background-color:#fffaf0;"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:6673760</ref><ref group="xtra">PMID:16593056</ref><ref group="xtra">PMID:913391</ref><ref group="xtra">PMID:1194289</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Meleagris gallopavo]]
[[Category: Meleagris gallopavo]]
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[[Category: Blundell, T L.]]
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[[Category: Blundell TL]]
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[[Category: Glover, I.]]
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[[Category: Glover I]]
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[[Category: Pitts, J.]]
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[[Category: Pitts J]]
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[[Category: Tickle, I.]]
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[[Category: Tickle I]]
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[[Category: Wood, S.]]
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[[Category: Wood S]]
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[[Category: Anisotropic refinement]]
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[[Category: Atomic resolution]]
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[[Category: Hormone]]
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[[Category: Pancrea]]
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[[Category: Pancreatic hormone]]
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[[Category: Polypeptide]]
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[[Category: Turkey]]
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Current revision

Anisotropic refinement of avian (turkey) pancreatic polypeptide at 0. 99 Angstroms resolution.

PDB ID 2bf9

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