1qjl

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[[Image:1qjl.png|left|200px]]
 
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==METALLOTHIONEIN MTA FROM SEA URCHIN (BETA DOMAIN)==
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The line below this paragraph, containing "STRUCTURE_1qjl", creates the "Structure Box" on the page.
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<StructureSection load='1qjl' size='340' side='right'caption='[[1qjl]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qjl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QJL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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{{STRUCTURE_1qjl| PDB=1qjl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qjl OCA], [https://pdbe.org/1qjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qjl RCSB], [https://www.ebi.ac.uk/pdbsum/1qjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qjl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTA_STRPU MTA_STRPU] Metallothioneins have a high content of cysteine residues that bind various heavy metals.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of [(113)Cd7]-metallothionein-A (MTA) of the sea urchin Strongylocentrotus purpuratus was determined by homonuclear(1)H NMR experiments and heteronuclear [(1)H, (113)Cd]-correlation spectroscopy. MTA is composed of two globular domains, an N-terminal four-metal domain of the amino acid residues 1 to 36 and a Cd4Cys11cluster, and a C-terminal three-metal domain including the amino acid residues 37 to 65 and a Cd3Cys9cluster. The structure resembles the known mammalian and crustacean metallothioneins, but has a significantly different connectivity pattern of the Cys-metal co-ordination bonds and concomitantly contains novel local folds of some polypeptide backbone segments. These differences can be related to variations of the Cys sequence positions and thus emphasize the special role of the cysteine residues in defining the structure of metallothioneins, both on the level of the domain architecture and the topology of the metal-thiolate clusters.
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===METALLOTHIONEIN MTA FROM SEA URCHIN (BETA DOMAIN)===
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NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA.,Riek R, Precheur B, Wang Y, Mackay EA, Wider G, Guntert P, Liu A, Kagi JH, Wuthrich K J Mol Biol. 1999 Aug 13;291(2):417-28. PMID:10438629<ref>PMID:10438629</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10438629}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1qjl" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10438629 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10438629}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1qjl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJL OCA].
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==Reference==
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<ref group="xtra">PMID:10438629</ref><ref group="xtra">PMID:2388267</ref><references group="xtra"/>
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[[Category: Strongylocentrotus purpuratus]]
[[Category: Strongylocentrotus purpuratus]]
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[[Category: Guntert, P.]]
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[[Category: Guntert P]]
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[[Category: Kaegi, J H.R.]]
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[[Category: Kaegi JHR]]
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[[Category: Liu, A.]]
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[[Category: Liu A]]
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[[Category: Mackay, E A.]]
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[[Category: Mackay EA]]
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[[Category: Precheur, B.]]
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[[Category: Precheur B]]
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[[Category: Riek, R.]]
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[[Category: Riek R]]
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[[Category: Wang, Y.]]
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[[Category: Wang Y]]
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[[Category: Wider, G.]]
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[[Category: Wider G]]
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[[Category: Wuthrich, K.]]
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[[Category: Wuthrich K]]
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[[Category: Detoxification]]
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[[Category: Metal-binding]]
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[[Category: Metallothionein]]
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[[Category: Radical scavenger]]
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Current revision

METALLOTHIONEIN MTA FROM SEA URCHIN (BETA DOMAIN)

PDB ID 1qjl

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