1h6o

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[[Image:1h6o.png|left|200px]]
 
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==Dimerisation domain from human TRF1==
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The line below this paragraph, containing "STRUCTURE_1h6o", creates the "Structure Box" on the page.
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<StructureSection load='1h6o' size='340' side='right'caption='[[1h6o]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h6o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H6O FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h6o OCA], [https://pdbe.org/1h6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h6o RCSB], [https://www.ebi.ac.uk/pdbsum/1h6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h6o ProSAT]</span></td></tr>
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{{STRUCTURE_1h6o| PDB=1h6o | SCENE= }}
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</table>
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== Function ==
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===DIMERISATION DOMAIN FROM HUMAN TRF1===
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[https://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_11545737}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 11545737 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/1h6o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_11545737}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h6o ConSurf].
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[[1h6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6O OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:11545737</ref><ref group="xtra">PMID:7502076</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chapman, L.]]
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[[Category: Large Structures]]
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[[Category: Fairall, L.]]
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[[Category: Chapman L]]
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[[Category: Rhodes, D.]]
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[[Category: Fairall L]]
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[[Category: Dimerisation]]
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[[Category: Rhodes D]]
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[[Category: Dna-binding]]
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[[Category: Nuclear protein]]
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[[Category: Telomere]]
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[[Category: Telomere binding]]
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[[Category: Trf1]]
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[[Category: Trfh]]
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Current revision

Dimerisation domain from human TRF1

PDB ID 1h6o

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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