1gsz

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[[Image:1gsz.png|left|200px]]
 
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==Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071==
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The line below this paragraph, containing "STRUCTURE_1gsz", creates the "Structure Box" on the page.
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<StructureSection load='1gsz' size='340' side='right'caption='[[1gsz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gsz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GSZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=R71:[4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE'>R71</scene></td></tr>
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{{STRUCTURE_1gsz| PDB=1gsz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsz OCA], [https://pdbe.org/1gsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gsz RCSB], [https://www.ebi.ac.uk/pdbsum/1gsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SQHC_ALIAD SQHC_ALIAD] Catalyzes the cyclization of squalene into hopene.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/1gsz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gsz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Squalene-hopene cyclase (SHC) catalyzes the conversion of squalene into pentacyclic compounds. It is the prokaryotic counterpart of the eukaryotic oxidosqualene cyclase (OSC) that catalyzes the steroid scaffold formation. Because of clear sequence homology, SHC can serve as a model for OSC, which is an attractive target for anticholesteremic drugs. We have established the crystal structure of SHC complexed with Ro48-8071, a potent inhibitor of OSC and therefore of cholesterol biosynthesis. Ro48-8071 is bound in the active-center cavity of SHC and extends into the channel that connects the cavity with the membrane. The binding site of Ro48-8071 is largely identical with the expected site of squalene; it differs from a previous model based on photoaffinity labeling. The knowledge of the inhibitor binding mode in SHC is likely to help develop more potent inhibitors for OSC.
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===CRYSTAL STRUCTURE OF A SQUALENE CYCLASE IN COMPLEX WITH THE POTENTIAL ANTICHOLESTEREMIC DRUG RO48-8071===
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Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071.,Lenhart A, Weihofen WA, Pleschke AE, Schulz GE Chem Biol. 2002 May;9(5):639-45. PMID:12031670<ref>PMID:12031670</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1gsz" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12031670}}, adds the Publication Abstract to the page
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*[[Squalene-hopene cyclase|Squalene-hopene cyclase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12031670 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12031670}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1gsz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSZ OCA].
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==Reference==
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<ref group="xtra">PMID:12031670</ref><ref group="xtra">PMID:9931258</ref><ref group="xtra">PMID:9295270</ref><ref group="xtra">PMID:9070455</ref><ref group="xtra">PMID:9162756</ref><references group="xtra"/>
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[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Alicyclobacillus acidocaldarius]]
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[[Category: Lenhart, A.]]
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[[Category: Large Structures]]
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[[Category: Pleschke, A E.W.]]
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[[Category: Lenhart A]]
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[[Category: Schulz, G E.]]
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[[Category: Pleschke AEW]]
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[[Category: Weihofen, W A.]]
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[[Category: Schulz GE]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Weihofen WA]]
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[[Category: Inhibitor interaction]]
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[[Category: Isomerase]]
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[[Category: Monotopic membrane protein]]
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[[Category: Oxidosqualene cyclase]]
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Current revision

Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071

PDB ID 1gsz

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