3i6z

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[[Image:3i6z.png|left|200px]]
 
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==3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine==
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The line below this paragraph, containing "STRUCTURE_3i6z", creates the "Structure Box" on the page.
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<StructureSection load='3i6z' size='340' side='right'caption='[[3i6z]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3i6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I6Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G6X:2-{6-[(4AS,6R,8AS)-6-HYDROXY-3-METHOXY-5,6,9,10-TETRAHYDRO-4AH-[1]BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-11(12H)-YL]HEXYL}-1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>G6X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3i6z| PDB=3i6z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i6z OCA], [https://pdbe.org/3i6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i6z RCSB], [https://www.ebi.ac.uk/pdbsum/3i6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i6z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/3i6z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i6z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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N-Piperidinopropyl-galanthamine (2) and N-saccharinohexyl-galanthamine (3) were used to investigate interaction sites along the active site gorge of Torpedo californica actylcholinesterase (TcAChE). The crystal structure of TcAChE-2 solved at 2.3 A showed that the N-piperidinopropyl group in 2 is not stretched along the gorge but is folded over the galanthamine moiety. This result was unexpected because the three carbon alkyl chain is just long enough for the bulky piperidine group to be placed above the bottleneck (Tyr121, Phe330) midway down the gorge. The crystal structure of TcAChE-3 at 2.2 A confirmed that a dual interaction with the sites at the bottom, and at the entrance of the gorge, enhances inhibitory activity: a chain of six carbon atoms has, in this class of derivatives, the correct length for optimal interactions with the peripheral anionic site (PAS).
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===3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine===
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Probing Torpedo californica Acetylcholinesterase Catalytic Gorge with Two Novel Bis-functional Galanthamine Derivatives.,Bartolucci C, Haller LA, Jordis U, Fels G, Lamba D J Med Chem. 2009 Dec 21. PMID:20025280<ref>PMID:20025280</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20025280}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3i6z" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20025280 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20025280}}
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==About this Structure==
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[[3i6z]] is a 1 chain structure of [[Acetylcholinesterase]] with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I6Z OCA].
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==See Also==
==See Also==
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*[[Acetylcholinesterase]]
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*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:20025280</ref><ref group="xtra">PMID:15563167</ref><ref group="xtra">PMID:10606746</ref><ref group="xtra">PMID:11119642</ref><ref group="xtra">PMID:11449566</ref><ref group="xtra">PMID:12140604</ref><ref group="xtra">PMID:16711737</ref><references group="xtra"/>
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__TOC__
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[[Category: Acetylcholinesterase]]
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</StructureSection>
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[[Category: Torpedo californica]]
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[[Category: Large Structures]]
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[[Category: Bartolucci, C.]]
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[[Category: Tetronarce californica]]
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[[Category: Lamba, D.]]
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[[Category: Bartolucci C]]
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[[Category: Alternative splicing]]
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[[Category: Lamba D]]
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[[Category: Alzheimer's disease]]
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[[Category: Bis-functional galanthamine derivative]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Cholinesterase]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Gpi-anchor]]
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[[Category: Hydrolase]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Neurotransmitter degradation]]
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[[Category: Serine esterase]]
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[[Category: Serine hydrolase]]
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[[Category: Synapse]]
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Current revision

3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine

PDB ID 3i6z

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